ReviewSeminars in cancer biology2011
Preclinical approaches to study the biology and treatment of brain metastases.
Review in Seminars in cancer biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain metastases from breast cancer using magnetic resonance imaging: A systematic review.Journal of medical radiation sciences · 2024Pooled it
- A real-world study on clinical features and prognosis of Chinese breast cancer patients with brain metastases.Frontiers in oncology · 2025Article
- Current preclinical models of brain metastasis.Clinical & experimental metastasis · 2024Review
- ATM-Inhibitor AZD1390 Is a Radiosensitizer for Breast Cancer CNS Metastasis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Article
- Review
- Brain Vascular Microenvironments in Cancer Metastasis.Biomolecules · 2022Review
- Preclinical Solid Tumor Models to Study Novel Therapeutics in Brain Metastases.Current protocols · 2021Article
- Clinical diagnosis and treatment of breast cancer with brain metastases and establishment of a prognostic model: a 10-year, single-center, real-world study of 559 cases.Annals of translational medicine · 2021Article
- A solitary brain metastasis as the only site of recurrence of HR positive, HER2 negative breast cancer: a case report and review of the literature.Journal of medical case reports · 2021Review
- High-resolution MRI demonstrates that more than 90% of small intracranial melanoma metastases develop in close relationship to the leptomeninges.Neuro-oncology · 2020Article
- Bevacizumab suppresses the growth of established non-small-cell lung cancer brain metastases in a hematogenous brain metastasis model.Clinical & experimental metastasis · 2020Article
- Patient-derived xenografts of central nervous system metastasis reveal expansion of aggressive minor clones.Neuro-oncology · 2020Article
- Immunomodulatory Drugs in Melanoma Brain Metastases.Discoveries (Craiova, Romania) · 2019Review
- Treatment of experimental human breast cancer and lung cancer brain metastases in mice by macitentan, a dual antagonist of endothelin receptors, combined with paclitaxel.Neuro-oncology · 2016Article
- Intertumor heterogeneity in vascularity and invasiveness of artificial melanoma brain metastases.Journal of experimental & clinical cancer research : CR · 2015Article
- Role of the endothelin axis in astrocyte- and endothelial cell-mediated chemoprotection of cancer cells.Neuro-oncology · 2014Article
- αB-crystallin: a novel regulator of breast cancer metastasis to the brain.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases.Journal of controlled release : official journal of the Controlled Release Society · 2013Article
- Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Roles for endothelin receptor B and BCL2A1 in spontaneous CNS metastasis of melanoma.Cancer research · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Metastatic spread to the central nervous system (CNS) is a common and devastating manifestation of major cancer types. Its incidence is associated with poor prognosis manifested by neurological deterioration leading to diminished quality of life and an extremely short median survival. CNS metastasis is becoming an increasingly important clinical problem. This is especially the case for certain types of cancers for which effective treatments of visceral disease are available. As a result of the present limitations in treating CNS metastases, this manifestation of tumor progression remains an unmet clinical need. Despite its significance, our general understanding of the mechanisms that regulate the brain-metastatic phenotype is currently meager. Both the analysis of mechanistic aspects of brain metastasis and the development of effective treatments necessitate the use of appropriate in vivo models that recapitulate the interaction of the tumor cells with the microenvironment of the brain. Here we review the available preclinical models of CNS metastasis and their use as tools to advance knowledge of the biology of the disease (with the aim of identifying relevant molecular determinants, prognostic biomarkers, and therapeutic targets) as well as examining effective approaches for treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.