ReviewBehavioural brain research2011
Contributions of ERK signaling in the striatum to instrumental learning and performance.
Review in Behavioural brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- The Signaling and Pharmacology of the Dopamine D1 Receptor.Frontiers in cellular neuroscience · 2021Pooled it
- PDE4 inhibitor rolipram dynamically regulates the balance between D1-MSNs and D2-MSNs in the DMS to modulate abnormal "Go" behavior associated with alcohol addiction.Acta pharmacologica Sinica · 2026Article
- Behavioral inflexibility through overtraining is mediated by reduced mGluR1/5 signaling capacity in the dorsolateral striatum.PLoS biology · 2025Article
- Sex and estradiol effects in the rodent dorsal striatum.The European journal of neuroscience · 2024Review
- Knocking Out TAAR5: A Pathway to Enhanced Neurogenesis and Dopamine Signaling in the Striatum.Cells · 2024Article
- Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders.Molecular psychiatry · 2024Article
- Understanding copy number variations through their genes: a molecular view on 16p11.2 deletion and duplication syndromes.Frontiers in pharmacology · 2024Review
- FermentedInternational journal of molecular sciences · 2022Article
- Aerobic exercise improves motor function and striatal MSNs-Erk/MAPK signaling in mice with 6-OHDA-induced Parkinson's disease.Experimental brain research · 2022Article
- The role of the bed nucleus of the stria terminalis in the motivational control of instrumental action.Frontiers in behavioral neuroscience · 2022Article
- Neural substrates of habit.Journal of neuroscience research · 2020Review
- Voluntary wheel running during adolescence distinctly alters running output in adulthood in male and female rats.Behavioural brain research · 2020Article
- Molecular mechanisms underlying striatal synaptic plasticity: relevance to chronic alcohol consumption and seeking.The European journal of neuroscience · 2019Article
- The Effect of ASIC3 Knockout on Corticostriatal Circuit and Mouse Self-grooming Behavior.Frontiers in cellular neuroscience · 2019Article
- Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants.Journal of neuroinflammation · 2018Article
- Regulation of habit formation in the dorsal striatum.Current opinion in behavioral sciences · 2018Article
- Male-specific deficits in natural reward learning in a mouse model of neurodevelopmental disorders.Molecular psychiatry · 2018Article
- Asiatic acid attenuates methamphetamine-induced neuroinflammation and neurotoxicity through blocking of NF-kB/STAT3/ERK and mitochondria-mediated apoptosis pathway.Journal of neuroinflammation · 2017Article
- Noncanonical regulation of insulin-mediated ERK activation by phosphoinositide 3-kinase γ.Molecular biology of the cell · 2017Article
- ERK/MAPK Signaling Is Required for Pathway-Specific Striatal Motor Functions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The striatum is critical for learning and decision making; however, the molecular mechanisms that govern striatum function are not fully understood. The extracellular signal regulated kinase (ERK) cascade is an important signaling pathway that underlies synaptic plasticity, cellular excitability, learning and arousal. This review focuses on the role of ERK signaling in striatum function. ERK is activated in the striatum by coordinated dopamine and glutamate receptor signaling, where it underlies corticostriatal synaptic plasticity and influences striatal cell excitability. ERK activation in the dorsal striatum is necessary for action-outcome learning and performance of goal-directed actions. In the ventral striatum, ERK is necessary for the motivating effects of reward-associated stimuli on instrumental performance. Dysregulation of ERK signaling in the striatum by repeated drug exposure contributes to the development of addictive behavior. These results highlight the importance of ERK signaling in the striatum as a critical substrate for learning and as a regulator of ongoing behavior. Furthermore, they suggest that ERK may be a suitable target for therapeutics to treat disorders of learning and decision making that arise from compromised striatum function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.