Trial reportNeurotoxicology2011
Perfusion deficit to cholinergic challenge in veterans with Gulf War Illness.
Trial report in Neurotoxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04586049 (Autonomic Dysfunction, Brain Blood Flow and Cognitive Decline in Veterans With Gulf War Illness), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Autonomic Dysfunction, Brain Blood Flow and Cognitive Decline in Veterans With Gulf War Illness
Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Comprehensive examination of resting state fMRI connectomics yields new insights into brain function deficits in Gulf War illness after accounting for heterogeneity in brain impairment across the ill veteran population.Neuroimage. Reports · 2024Article
- Review
- The Department of Veterans Affairs Gulf War Veterans' Illnesses Biorepository: Supporting Research on Gulf War Veterans' Illnesses.Brain sciences · 2021Article
- Gulf War veterans exhibit broadband sleep EEG power reductions in regions overlying the frontal lobe.Life sciences · 2021Article
- Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies.Pharmacology & therapeutics · 2021Review
- Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness.Journal of neuroinflammation · 2018Article
- Dynamic cerebral autoregulation is impaired in Veterans with Gulf War Illness: A case-control study.PloS one · 2018Article
- Subcortical brain atrophy in Gulf War Illness.Experimental brain research · 2017Article
- A Neuroimmune Model of Gulf War Illness.Journal of environment and health sciences · 2017Article
- Enhanced Cholinergic Activity Improves Cerebral Blood Flow during Orthostatic Stress.Frontiers in neurology · 2017Article
- Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment.Cortex; a journal devoted to the study of the nervous system and behavior · 2016Review
- Effects of low-level sarin and cyclosarin exposure on hippocampal subfields in Gulf War Veterans.Neurotoxicology · 2014Article
- Severe life stress and oxidative stress in the brain: from animal models to human pathology.Antioxidants & redox signaling · 2013Review
- Visual event-related potentials as markers of hyperarousal in Gulf War illness: evidence against a stress-related etiology.Psychiatry research · 2013Article
- Lipidomic profiling of phosphocholine-containing brain lipids in mice with sensorimotor deficits and anxiety-like features after exposure to Gulf War agents.Neuromolecular medicine · 2012Article
- FMRI reveals abnormal central processing of sensory and pain stimuli in ill Gulf War veterans.Neurotoxicology · 2012Article
- Hippocampal dysfunction in Gulf War veterans: investigation with ASL perfusion MR imaging and physostigmine challenge.Radiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
A highly plausible etiology for Gulf War Illness (GWI) is that the neural damage and cognitive deficits are associated with excessive exposure to cholinesterase-inhibiting cholinergic stimulants. Our previous SPECT study provided strong indication that cerebral blood flow (CBF) in veterans with GWI may be different from those of unaffected control veterans. The present study confirmed and extended previous findings that patients with GWI have abnormal response to an inhibitory cholinergic challenge, physostigmine infusion, when compared to age-gender-education matched control veterans. The MRI-based arterial spin labeling (ASL) and phase-contrast techniques have several key advantages over SPECT, including shorter experiment duration, complete non-invasiveness, and higher spatial and temporal resolutions, and therefore may provide a cost-effective biomarker for characterization of GWI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.