ArticleComprehensive psychiatry
Effect of comorbid alcohol and drug use disorders on premature death among unipolar and bipolar disorder decedents in the United States, 1999 to 2006.
Article in Comprehensive psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03220776 (Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Sex-Specific Association of Alcohol Use Disorder With Suicide Mortality: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Brain changes in early-onset bipolar and unipolar depressive disorders: a systematic review in children and adolescents.European child & adolescent psychiatry · 2014Pooled it
- Additive impulsivity and emotion dysregulation in adolescents with comorbid bipolar and substance use disorder: a cross-sectional factorial study.Frontiers in psychiatry · 2026Article
- Multimodal Machine Learning Prediction of 12-Month Suicide Attempts in Bipolar Disorder.Bipolar disorders · 2025Article
- Can adaptive hyperactivation result in a positive score on the Mood Disorder Questionnaire? Evidence from a case-control study over a community survey.Frontiers in psychiatry · 2025Article
- Certified Community Behavioral Health Clinic Services for Clients With Co-occurring Disorders: A Latent Class Approach.Psychiatric services (Washington, D.C.) · 2024Article
- Hyperactivity and Risk for Dysregulation of Mood, Energy, and Social Rhythms Syndrome (DYMERS): Standardization of a Simple One-Item Screener versus the Mood Disorder Questionnaire (MDQ).Journal of clinical medicine · 2024Article
- Real-world clinical determinants of alcohol dependence in outpatients with bipolar disorder: a multicenter treatment survey for bipolar disorder in psychiatric outpatient clinics with 2,392 participants.Frontiers in psychiatry · 2024Article
- Does Screening for Bipolar Disorders Identify a "Dysregulation of Mood, Energy, and Social Rhythms Syndrome" (DYMERS)? A Heuristic Working Hypothesis.Journal of clinical medicine · 2023Article
- Screening, Genetic Variants, and Bipolar Disorders: Can Useful Hypotheses Arise from the Sum of Partial Failures?Clinics and practice · 2023Article
- Analysis of Multiple Causes of Death: A Review of Methods and Practices.Epidemiology (Cambridge, Mass.) · 2023Review
- Opioid Use Disorder Among Clients of Community Mental Health Clinics: Prevalence, Characteristics, and Treatment Willingness.Psychiatric services (Washington, D.C.) · 2022Article
- Developing "MinDag" - an app to capture symptom variation and illness mechanisms in bipolar disorder.Frontiers in medical technology · 2022Article
- Organizational Capacity and Readiness to Provide Medication for Individuals with Co-Occurring Alcohol Use Disorders in Public Mental Health Settings.Administration and policy in mental health · 2021Article
- Comparisons between suicide in persons with serious mental illness, other mental disorders, or no known mental illness: Results from 37 U.S. states, 2003-2017.Schizophrenia research · 2021Article
- Comorbid Bipolar and Alcohol Use Disorder-A Therapeutic Challenge.Frontiers in psychiatry · 2021Review
- Outcomes of two quality improvement implementation interventions for depression services in adults with substance use problems.The American journal of drug and alcohol abuse · 2020Article
- Clinical Correlates of Alcohol Use Disorder in Depressed Patients with Unipolar and Bipolar Disorder.Psychiatry investigation · 2019Article
- Risk factors for suicide in bipolar disorder: a cohort study of 12 850 patients.Acta psychiatrica Scandinavica · 2018Article
- No differences in manic-like behaviors between voluntary ethanol and water drinking in Lateral Hypothalamic Kindled (LHK) alcohol preferring rats.Psychiatry research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to quantify the effect of comorbid alcohol and drug use disorders on premature death, as reflected by the manner of death (suicide and other unnatural death versus natural death) and the age at death, among decedents with unipolar and bipolar disorders.
methodsThis study is based on the US Multiple Cause of Death public-use data files for 1999 to 2006. Secondary data analysis was conducted comparing decedents with unipolar/bipolar disorders and decedents with all other causes of death, based on the death records of 19,052,468 decedents in the Multiple Cause of Death data files who died at 15 years and older. Poisson regression models were used to derive prevalence ratios to assess the effect of comorbid substance use disorders (SUD) on the risks for being an unnatural death among mood disorder deaths. Multiple-cause life table analysis and mean age at death were used to quantify the effect of comorbid SUDs on premature mortality among mood disorder deaths.
resultsPrevalence of comorbid SUDs was higher among unipolar and bipolar disorder deaths than that among all other deaths. Among unipolar and bipolar disorder deaths, comorbid SUDs were associated with elevated risks for suicide and other unnatural death in both men and women (prevalence ratios ranging 1.49-9.46, P < .05). They also were associated with reductions in mean ages at death (ranging 11.7-33.8 years, P < .05). In general, these effects were much stronger for drug use disorders than for alcohol use disorders. Both SUDs had stronger effects on suicide among women, whereas their effects on other unnatural deaths were stronger among men.
conclusionsThis study is among the first to provide population mortality-based evidence to further establish comorbid SUD as one of the key risk factors for premature death among individuals with unipolar or bipolar disorders in the United States. Clinicians need to be aware of the potentially lethal risk associated with these comorbid conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.