Trial reportAmerican heart journal2010
Anthropometric measures after Fontan procedure: implications for suboptimal functional outcome.
Trial report in American heart journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Health-Related Quality of Life in Children, Adolescents, and Adults With a Fontan Circulation: A Meta-Analysis.Journal of the American Heart Association · 2020Pooled it
- Passive range of motion exercise to enhance growth in infants following the Norwood procedure: a safety and feasibility trial.Cardiology in the young · 2017Trial
- Growth Asymmetry, Head Circumference, and Neurodevelopmental Outcomes in Infants with Single Ventricles.The Journal of pediatrics · 2016Trial
- Longitudinal assessment of growth in hypoplastic left heart syndrome: results from the single ventricle reconstruction trial.Journal of the American Heart Association · 2014Trial
- Factors impacting echocardiographic imaging after the Fontan procedure: a report from the pediatric heart network fontan cross-sectional study.Echocardiography (Mount Kisco, N.Y.) · 2013Trial
- Growth Failure in Children with Congenital Heart Disease.Children (Basel, Switzerland) · 2025Review
- Nutritional Management of Patients with Fontan Circulation: A Potential for Improved Outcomes from Birth to Adulthood.Nutrients · 2022Review
- Body Mass Index Trajectory and Outcome Post Fontan Procedure.Journal of the American Heart Association · 2022Article
- Sizing Up Fontan Failure: Association with Increasing Weight in Adulthood.Pediatric cardiology · 2021Article
- Body Composition and Exercise Performance in Youth With a Fontan Circulation: A Bio-Impedance Based Study.Journal of the American Heart Association · 2020Observational
- End-Organ Function and Exercise Performance in Patients With Fontan Circulation: What Characterizes the High Performers?Journal of the American Heart Association · 2020Article
- Longitudinal study of anthropometry in Fontan survivors: Pediatric Heart Network Fontan study.American heart journal · 2020Article
- Translation of the Frailty Paradigm from Older Adults to Children with Cardiac Disease.Pediatric cardiology · 2020Article
- Childhood Obesity, Endothelial Cell Activation, and Critical Illness.Frontiers in pediatrics · 2020Review
- Longitudinal growth in patients with single ventricle cardiac disease receiving tube-assisted feeds.Congenital heart disease · 2019Article
- High Overweight and Obesity in Fontan Patients: A 20-Year History.Pediatric cardiology · 2016Article
- Growth and Obesity Among Older Single Ventricle Patients Presenting for Fontan Conversion.World journal for pediatric & congenital heart surgery · 2015Article
- Deficits in bone density and structure in children and young adults following Fontan palliation.Bone · 2015Article
- Usefulness of insulin like growth factor 1 as a marker of heart failure in children and young adults after the Fontan palliation procedure.The American journal of cardiology · 2015Article
- Lean mass deficits, vitamin D status and exercise capacity in children and young adults after Fontan palliation.Heart (British Cardiac Society) · 2014Article
Corrections and comments
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Authors and funding
11 authors at 10 institutions in 2 countries.
Funding
Abstract
backgroundAbnormal height and adiposity are observed after the Fontan operation. These abnormalities may be associated with worse functional outcome.
methodsWe analyzed data from the National Heart, Lung, and Blood Institute Pediatric Heart Network cross-sectional study of Fontan patients. Groups were defined by height (z-score<-1.5 or≥-1.5) and body mass index (body mass index [BMI] z-score<-1.5 or -1.5 to 1.5 or≥1.5). Associations of anthropometric measures with measurements from clinical testing (exercise, echocardiography, magnetic resonance imaging) were determined adjusting for demographics, anatomy, and pre-Fontan status. Relationships between anthropometric measures and functional health status (FHS) were assessed using the Child Health Questionnaire.
resultsMean age of the cohort (n=544) was 11.9±3.4 years. Lower height-z patients (n=124, 23%) were more likely to have pre-Fontan atrioventricular valve regurgitation (P=.029), as well as orthopedic and developmental problems (both P<.001). Lower height-z patients also had lower physical and psychosocial FHS summary scores (both P<.01). Higher BMI-z patients (n=45, 8%) and lower BMI-z patients (n=53, 10%) did not have worse FHS compared to midrange BMI-z patients (n=446, 82%). However, higher BMI-z patients had higher ventricular mass-to-volume ratio (P=.03) and lower % predicted maximum work (P=.004) compared to midrange and lower BMI-z patients.
conclusionsAbnormal anthropometry is common in Fontan patients. Shorter stature is associated with poorer FHS and non-cardiac problems. Increased adiposity is associated with more ventricular hypertrophy and poorer exercise performance, which may have significant long-term implications in this at-risk population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.