ArticleExperimental cell research2011
Mis-localization of Arp2 mRNA impairs persistence of directional cell migration.
Article in Experimental cell research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Folylpolyglutamate synthetase mRNA G-quadruplexes regulate its cell protrusion localization and enhance a cancer cell invasive phenotype upon folate repletion.BMC biology · 2023Article
- Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes.PLoS pathogens · 2016Article
- Proteomic analysis identifies an NADPH oxidase 1 (Nox1)-mediated role for actin-related protein 2/3 complex subunit 2 (ARPC2) in promoting smooth muscle cell migration.International journal of molecular sciences · 2013Article
- Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.The Journal of clinical investigation · 2013Article
- Molecular insights into intracellular RNA localization.International review of cell and molecular biology · 2013Review
- Immediate translation of Formin DIAPH1 mRNA after its exiting the nucleus is required for its perinuclear localization in fibroblasts.PloS one · 2013Article
- Principles and roles of mRNA localization in animal development.Development (Cambridge, England) · 2012Review
- hnRNP Q regulates Cdc42-mediated neuronal morphogenesis.Molecular and cellular biology · 2012Article
- How and why does Dia1 mRNA localize?Communicative & integrative biology · 2011Article
- An RNA-zipcode-independent mechanism that localizes Dia1 mRNA to the perinuclear ER through interactions between Dia1 nascent peptide and Rho-GTP.Journal of cell science · 2011Article
- Control of cell migration through mRNA localization and local translation.Wiley interdisciplinary reviews. RNAReview
- Actin binding proteins: their ups and downs in metastatic life.Cell adhesion & migrationReview
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Arp2/3 complex is an actin polymerization nucleator and localized in the leading protrusions of migrating cells. It has been unclear how this complex is targeted to the protrusions and whether its localization is functionally important. We previously demonstrated that mRNAs encoding for the subunits of the complex were localized in the protrusions of fibroblasts, suggesting a mechanism to target the complex to the protrusions. We here present data demonstrating the importance of Arp2/3 complex mRNA localization in directional cell migration. Using a novel mechanism by which Dia1 mRNA is targeted to the perinuclear endoplasmic reticulum, we redirected the mRNA encoding Arp2, a subunit of the Arp2/3 complex, to the perinuclear region in fibroblasts. Knockdown of Arp2 alone caused dramatic reduction of the complex and resulted in narrow protrusions, increased random cell migration speed and loss of directionality. Rescue with a protrusion-localizing Arp2 mRNA restored normal cell migration behavior, whereas rescue with a mis-localizing Arp2 mRNA failed to restore speed and directionality. These results demonstrate that localization of Arp2/3 complex mRNAs in the leading protrusions is functionally important for directional cell migration.
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