ArticleDevelopmental biology2011
C. elegans Dicer interacts with the P-granule component GLH-1 and both regulate germline RNPs.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 46 citations in OpenAlex.
- An updated compendium of Caenorhabditis elegans RNA-binding proteins and their regulation.G3 (Bethesda, Md.) · 2025Article
- A unified framework governing the establishment and maintenance of transgenerational epigenetic inheritance.Genetics · 2025Article
- Caenorhabditis elegans germ granules accumulate hundreds of low translation mRNAs with no systematic preference for germ cell fate regulators.Development (Cambridge, England) · 2024Article
- P-body-like condensates in the germline.Seminars in cell & developmental biology · 2024Review
- A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing.Cell reports · 2022Article
- Review
- Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans.Developmental cell · 2022Article
- DICER: structure, function, and regulation.Biophysical reviews · 2021Review
- Small RNAs and chromatin in the multigenerational epigenetic landscape ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- ZSP-1 is a Z granule surface protein required for Z granule fluidity and germline immortality in Caenorhabditis elegans.The EMBO journal · 2021Article
- New Family Members of FG Repeat Proteins and Their Unexplored Roles During Phase Separation.Frontiers in cell and developmental biology · 2021Review
- Germ Granules Allow Transmission of Small RNA-Based Parental Responses in the "Germ Plasm".iScience · 2020Review
- Germ Granules Coordinate RNA-Based Epigenetic Inheritance Pathways.Developmental cell · 2019Article
- The P Granules of C. elegans: A Genetic Model for the Study of RNA-Protein Condensates.Journal of molecular biology · 2018Review
- Nuclear re-localization of Dicer in primary mouse embryonic fibroblast nuclei following DNA damage.PLoS genetics · 2018Article
- Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage.The Journal of cell biology · 2017Article
- The RNAi Inheritance Machinery ofGenetics · 2017Article
- ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans.PLoS genetics · 2017Article
- Small RNA in situ hybridization in Caenorhabditis elegans, combined with RNA-seq, identifies germline-enriched microRNAs.Developmental biology · 2016Article
- RNAi Screen Identifies Novel Regulators of RNP Granules in the Caenorhabditis elegans Germ Line.G3 (Bethesda, Md.) · 2016Article
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6 authors at 2 institutions in 1 country.
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Abstract
P granules, ribonucleoprotein (RNP) complexes specific to the cytoplasmic side of the nuclear pores of Caenorhabditis elegans germ cells, are implicated in post-transcriptional control of maternally-transcribed mRNAs. Here we show a relationship in C. elegans of Dicer, the riboendonuclease processing enzyme of the RNA interference and microRNA pathways, with GLH-1, a germline-specific RNA helicase and a constitutive component of P granules. Based on results from GST-pull-downs and immunoprecipitations, GLH-1 binds DCR-1 and this binding does not require RNA. Both GLH-1 protein and glh-1 mRNA levels are reduced in the dcr-1(ok247) null mutant background; conversely, a reduction of DCR-1 protein is observed in the glh-1(gk100) deletion strain. Thus, in the C. elegans germline, DCR-1 and GLH-1 are interdependent. In addition, evidence indicates that DCR-1 protein levels, like those of GLH-1, are likely regulated by the Jun N-terminal kinase (JNK), KGB-1. In adult germ cells, DCR-1 is found in uniformly-distributed, small puncta both throughout the cytoplasm and the nucleus, on the inner side of nuclear pores, and associated with P granules. In arrested oocytes, GLH-1 and DCR-1 re-localize to cytoplasmic and cortically-distributed RNP granules and are necessary to recruit other components to these complexes. We predict that the GLH-1/DCR-1 complex may function in the transport, deposition, or regulation of maternally-transcribed mRNAs and their associated miRNAs.
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