ArticleProceedings of the National Academy of Sciences of the United States of America1990
Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 42 citations in OpenAlex.
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- Analyses of recombinant stereotypic IGHV3-21-encoded antibodies expressed in chronic lymphocytic leukemia.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Receptor editing occurs frequently during normal B cell development.The Journal of experimental medicine · 1998Article
- Immunochemical and molecular characterization of anti-RNA polymerase I autoantibodies produced by tight skin mouse.The Journal of clinical investigation · 1993Article
- Molecular characteristics of anti-polysaccharide antibodies.Springer seminars in immunopathology · 1993Review
- Molecular characterization of five human anti-human immunodeficiency virus type 1 antibody heavy chains reveals extensive somatic mutation typical of an antigen-driven immune response.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.The Journal of experimental medicine · 1991Article
- Pairing of VK and VK gene families in self-reactive antibodies.Journal of clinical immunology · 1990Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Frequencies of 25 immunoglobulin heavy-chain and kappa light-chain variable (VH + V kappa) gene-family pairings expressed in splenic B-cell populations were determined by hybridization of VH- and V kappa-family-specific DNA probes to mitogen-induced B-cell colonies from C57BL/6 mice or hybridomas derived from BALB/c and NZB mice. Both analyses support the conclusion that VH and V kappa gene families pair without bias; as would be expected for random association, the frequencies of specific VH + V kappa pairs may be estimated by the product of the independent VH and V kappa frequencies. Based upon the frequencies at which 9 VH and 12 V kappa gene families are expressed, we calculated the expected usage for approximately 100 VH + V kappa family pairings in neonatal and adult C57BL/6 mice. Variability in the expression of such VH + V kappa pairings is considerable; pairs representing greater than 10% to less than 0.01% of the splenic B-cell population occur. This variability is most pronounced in the neonate, where 6 VH + V kappa family pairs account for nearly 40% of all mitogen-reactive B cells. As the neonate matures, the distribution of frequencies for VH + V kappa pairings becomes more nearly uniform. This process may underlie the patterned acquisition of humoral immune responsiveness.
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Registered trials
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