ArticleMolecular and cellular neurosciences2011
NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1α.
Article in Molecular and cellular neurosciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- Neurofunctional and Clinical Effects of Intranasal Human Recombinant Nerve Growth Factor in Children with Acquired Brain Injury.Pharmaceuticals (Basel, Switzerland) · 2026Review
- VEGF and Neurotrophins Interaction in the Retinal Neurovascular Unit Homeostasis: A Target for Ocular Disease Treatment and Management.Pharmaceutical research · 2026Review
- Antidepressant and Related Neurobiological and Neurophysiological Effects of Add-On Transcranial Direct Current Stimulation in Major Depressive Disorder with Residual Symptoms: A Randomized, Double-Blind Clinical Trial Protocol.Methods and protocols · 2025Article
- 3D imaging reveals changes in the neurovascular architecture of the murine calvarium with aging.Bone research · 2025Article
- Cobalt ions-derived nanoenzyme array for endosseous neural network reconstruction and osseointegration.Bioactive materials · 2024Article
- The Protective Effects of Neurotrophins and MicroRNA in Diabetic Retinopathy, Nephropathy and Heart Failure via Regulating Endothelial Function.Biomolecules · 2022Review
- Ionophore Ability of Carnosine and Its Trehalose Conjugate Assists Copper Signal in Triggering Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Activation In Vitro.International journal of molecular sciences · 2021Article
- TGFβ-Neurotrophin Interactions in Heart, Retina, and Brain.Biomolecules · 2021Review
- NGF in Inflammatory and Neurodegenerative Diseases of the Eye: New Findings Supporting Neuroprotection and Proper Tissue Remodeling in Vitreoretinal Disorders.Advances in experimental medicine and biology · 2021Article
- In Search of a Dose: The Functional and Molecular Effects of Exercise on Post-stroke Rehabilitation in Rats.Frontiers in cellular neuroscience · 2020Article
- Nerves in Bone: Evolving Concepts in Pain and Anabolism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Review
- HDAC5 promotes optic nerve regeneration by activating the mTOR pathway.Experimental neurology · 2019Article
- DNMT1, a Novel Regulator Mediating mTORC1/mTORC2 Pathway-Induced NGF Expression in Schwann Cells.Neurochemical research · 2018Article
- Administration of CoClInternational journal of medical sciences · 2018Article
- Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ovarian cancer cells and endothelial cells.Therapeutic advances in medical oncology · 2018Article
- Mesenchymal Stem Cell Migration and Proliferation Are Mediated by Hypoxia-Inducible Factor-1α Upstream of Notch and SUMO Pathways.Stem cells and development · 2017Article
- Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Review
- Novel insights into the effect of vitamin B₁₂ and omega-3 fatty acids on brain function.Journal of biomedical science · 2016Review
- Anti-apoptotic role and clinical relevance of neurotrophins in diffuse large B-cell lymphomas.British journal of cancer · 2015Article
- Isolation and Characterization of Human Lung Lymphatic Endothelial Cells.BioMed research international · 2015Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Communication between the vasculature and nervous system is important during embryogenesis but the molecular mechanisms mediating this are ill-defined. We evaluated the molecular mechanisms by which Nerve Growth Factor (NGF) and Brain-derived neurotrophic factor (BDNF) regulate VEGF production. NGF activation of TrkA causes a marked increase in VEGF secretion by neuronal cells. The NGF induced increase in VEGF is accompanied by an increase in HIF-1α. Pharmacologic inhibitors of the Trk tyrosine kinase, PI-3 kinase and mTOR paths prevent NGF stimulated increases in HIF-1α and VEGF. NGF induced increase in VEGF transcription is dependent on a hypoxia response element (HRE) in the VEGF promoter. Mutation of the HRE or siRNA mediated silencing of HIF-1α expression blocks NGF induced increases in VEGF transcription. In primary cultures of TrkA expressing neurons from dorsal root ganglion, NGF induces VEGF expression that is accompanied by increases in HIF-1α but not HIF-2α expression. In CGN neurons, BDNF induces VEGF that is dependent on induction of HIF-1α. Our study indicates that neurotrophin activation of Trk stimulates an increase in VEGF transcription that is mediated by induction of HIF-1α.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.