Trial reportJournal of hepatology2011
Predictors and effects of alcohol use on liver function among young HCV-infected injection drug users in a behavioral intervention.
Trial report in Journal of hepatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Efficacy of psychosocial interventions to reduce alcohol use in comorbid alcohol use disorder and alcohol-related liver disease: a systematic review of randomized controlled trials.Alcohol and alcoholism (Oxford, Oxfordshire) · 2023Pooled it
- Psychosocial interventions to reduce alcohol consumption in concurrent problem alcohol and illicit drug users.The Cochrane database of systematic reviews · 2018Pooled it
- Efficacy of Psychosocial Interventions in Inducing and Maintaining Alcohol Abstinence in Patients With Chronic Liver Disease: A Systematic Review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2016Pooled it
- Simultaneous Management of Alcohol Use Disorder and Liver Disease: A Systematic Review and Meta-analysis.Journal of addiction medicinePooled it
- Infectious Diseases Among People Experiencing Homelessness: A Systematic Review of the Literature in the United States and Canada, 2003-2022.Public health reports (Washington, D.C. : 1974)Pooled it
- Changes in alcohol use during hepatitis C treatment in persons who inject drugs.Journal of viral hepatitis · 2022Trial
- Prospective Longitudinal Substance Use Patterns in Patients Preparing for Hepatitis C Treatment.Journal of dual diagnosisTrial
- Implementation of Mobile-Based Programs for Alcohol Cessation in the Treatment of Alcohol-associated Liver Disease: Protocol for a Type 1 Hybrid Implementation-Effectiveness Trial.JMIR research protocols · 2026Article
- Treatment of substance use disorders in patients with chronic liver disease.Clinical liver disease · 2022Review
- Diagnosis and Management of Alcohol Use Disorder in Patients with Liver Disease: Lights and Shadows.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Opioid epidemic and liver disease.JHEP reports : innovation in hepatology · 2019Review
- Integrating Care for Patients With Chronic Liver Disease and Mental Health and Substance Use Disorders.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2018Article
- Impact of HCV treatment and depressive symptoms on adherence to HAART among HIV-HCV-coinfected patients: results from the ANRS-CO13-HEPAVIH cohort.Antiviral therapy · 2014Article
- Clinical chemistry profiles in injection heroin users from Coastal Region, Kenya.BMC clinical pathology · 2014Article
- Predictors of alcohol use among rural drug users after disclosure of hepatitis C virus status.Journal of studies on alcohol and drugs · 2013Article
- Risky alcohol use and serum aminotransferase levels in HIV-infected adults with and without hepatitis C.Journal of studies on alcohol and drugs · 2013Article
- Hazardous alcohol consumption among young adult IDU and its association with high risk behaviors.Drug and alcohol dependence · 2013Article
- Current and future disease progression of the chronic HCV population in the United States.PloS one · 2013Article
Corrections and comments
- Commented on byFocus.2011
Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsHepatitis C virus (HCV) screening can provide opportunities to reduce disease progression through counseling against alcohol use, but empirical data on this issue are sparse. We determined the efficacy of a behavioral intervention in reducing alcohol use among young, HCV-infected injection drug users (IDUs) (n=355) and assessed whether changes in liver enzymes were associated with changes in alcohol consumption.
methodsBoth the intervention and attention-control groups were counseled to avoid alcohol use, but the intervention group received enhanced counseling. Logistic regression, ANOVA, and continuous time Markov models were used to identify factors associated with alcohol use, changes in mean ALT and AST levels, and change in alcohol use post-intervention.
resultsSix months post-intervention, alcohol abstinence increased 22.7% in both groups, with no difference by intervention arm. Transition from alcohol use to abstinence was associated with a decrease in liver enzymes, with a marginally greater decrease in the intervention group (p=0.05 for ALT; p=0.06 for AST). In multivariate Markov models, those who used marijuana transitioned from alcohol abstinence to consumption more rapidly than non-users (RR=3.11); those who were homeless transitioned more slowly to alcohol abstinence (RR=0.47); and those who had ever received a clinical diagnosis of liver disease transitioned more rapidly to abstinence (RR=1.88).
conclusionsAlthough, behavioral counseling to reduce alcohol consumption among HCV-infected IDUs had a modest effect, reductions in alcohol consumption were associated with marked improvements in liver function. Interventions to reduce alcohol use among HCV-infected IDUs may benefit from being integrated into clinical care and monitoring of HCV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.