ArticleRespiratory medicine2011
Clinical predictors of frequent exacerbations in subjects with severe chronic obstructive pulmonary disease (COPD).
Article in Respiratory medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02268708 (Evaluation of Post-operative Respiratory Complications After Thoracic Surgery in Patients With COPD), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Post-operative Respiratory Complications After Thoracic Surgery in Patients With COPD
Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Early response to inhaled bronchodilators and corticosteroids as a predictor of 12-month treatment responder status and COPD exacerbations.International journal of chronic obstructive pulmonary disease · 2016Trial
- Article
- A protein risk score for all-cause and respiratory-specific mortality in non-Hispanic white and African American individuals who smoke.Scientific reports · 2024Article
- Diffusing Capacity as a Predictor of Hospitalizations in a Clinical Cohort of Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2024Article
- Chronic Obstructive Pulmonary Disease with Frequent Exacerbator Phenotype: What is Different in these Patients?Tanaffos · 2022Article
- Increased mortality associated with frequent exacerbations in COPD patients with mild-to-moderate lung function impairment, and smokers with normal spirometry.Respiratory medicine: X · 2021Article
- Article
- A clinical prediction model for hospitalized COPD exacerbations based on "treatable traits".International journal of chronic obstructive pulmonary disease · 2019Article
- Clinical burden of illness among patients with severe eosinophilic COPD.International journal of chronic obstructive pulmonary disease · 2019Article
- Critical Inhaler Handling Error Is an Independent Risk Factor for Frequent Exacerbations of Chronic Obstructive Pulmonary Disease: Interim Results of a Single Center Prospective Study.International journal of chronic obstructive pulmonary disease · 2019Article
- Clinical characteristics of chronic bronchitic, emphysematous and ACOS phenotypes in COPD patients with frequent exacerbations.International journal of chronic obstructive pulmonary disease · 2017Article
- Severe COPD cases from Korea, Poland, and USA have substantial differences in respiratory symptoms and other respiratory illnesses.International journal of chronic obstructive pulmonary disease · 2017Article
- Observational
- Prevention of Exacerbations in Chronic Obstructive Pulmonary Disease: Knowns and Unknowns.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2014Review
- Predictors of exacerbations of asthma and COPD during one year in primary care.Family practice · 2013Article
- Development and validation of a model to predict the risk of exacerbations in chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2013Article
- Is 'GOLD' standard for the management of COPD in clinical practice?Drugs in context · 2012Article
- Comparison of clinico-physiologic and CT imaging risk factors for COPD exacerbation.Journal of Korean medical science · 2011Article
- Predicting Hospitalization Due to COPD Exacerbations in Swedish Primary Care Patients Using Machine Learning - Based on the ARCTIC Study.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundAcute exacerbations are a significant source of morbidity and mortality associated with chronic obstructive pulmonary disease. Among individuals with COPD, some patients suffer an inordinate number of exacerbations while others remain relatively protected. We undertook a study to determine the clinical factors associated with "frequent exacerbator" status within a population of subjects with severe COPD.
methodsCase-control cohort recruited from two Boston-area practices. All subjects had GOLD stage 3 or 4 (FEV(1) ≤ 50% predicted) COPD. "Frequent exacerbators" (n = 192) had an average of ≥2 moderate-to-severe exacerbations per year while "non-exacerbators" (n = 153) had no exacerbations in the preceding 12 months. Multivariate logistic regression was performed to determine the significant clinical predictors of "frequent exacerbator" status.
resultsPhysician-diagnosed asthma was a significant predictor of frequent exacerbations. Within a subset of our cohort, the modified Medical Research Council dyspnea score and FEF (25-75%) predicted were also significant clinical predictors of frequent exacerbator status (p < 0.05). Differences in exacerbation frequency were not found to be due to increased current tobacco use or decreased rates of maintenance medication use.
conclusionsWithin our severe COPD cohort, a history of physician-diagnosed asthma was found to be a significant clinical predictor of frequent exacerbations. Although traditional risk factors such as decreased FEV(1)% predicted were not significantly associated with frequent exacerbator status, lower mid-expiratory flow rates, as assessed by FEF (25-75%) predicted, were significantly associated with frequent exacerbations in a subset of our cohort.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.