Evidence map›Paper›PMID 21145529›Full record

ArticleAmerican journal of obstetrics and gynecology2011

Midpregnancy levels of angiogenic markers in relation to maternal characteristics.

Renée S Mijal, Claudia B Holzman, Sarosh Rana, S Ananth Karumanchi, Jianling Wang, Alla Sikorskii

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in American journal of obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  4. Maternal risk of hypertension 7-15 years after pregnancy: clues from the placenta.BJOG : an international journal of obstetrics and gynaecology · 2021
    Article
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  8. Review
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  11. Review
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  13. Article
  14. Review
  15. New developments in the pathogenesis of preeclampsia.Advances in chronic kidney disease · 2013
    Review
  16. Article
  17. Mid-pregnancy levels of angiogenic markers as indicators of pathways to preterm delivery.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2012
    Article
  18. Maternal plasma concentrations of angiogenic/anti-angiogenic factors are of prognostic value in patients presenting to the obstetrical triage area with the suspicion of preeclampsia.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2011
    Article
  19. Maternal angiogenic profile in pregnancies that remain normotensive.European journal of obstetrics, gynecology, and reproductive biology · 2011
    Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Renée S MijalDepartment of Epidemiology, Michigan State University, East Lansing, MI, USA.
Claudia B Holzman
Sarosh Rana
S Ananth Karumanchi
Jianling Wang
Alla Sikorskii
Michigan State University · USHarvard University · US

Funding

Etiologic Heterogeneity in Preterm DeliveryR01HD034543 · NICHD · MICHIGAN STATE UNIVERSITY · PI HOLZMAN, CLAUDIA B. · 1997 to 2005
$5.3M
Development of Scholars in Ob-Gyn for the 21th CenturyK12HD001255 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BARBIERI, ROBERT L · 1999 to 2009
$2.6M
Training Program in Perinatal EpidemiologyT32HD046377 · NICHD · MICHIGAN STATE UNIVERSITY · PI PANETH, NIGEL SEFTON · 2005 to 2014
$2.5M
Immune System Gene Polymorphisms and Preterm DeliveryU01DP000143 · DP · MICHIGAN STATE UNIVERSITY · PI HOLZMAN, CLAUDIA B. · 2005 to 2009
$2.1M
Howard Hughes Medical InstituteNCCDPHP CDC HHS U01 DP000143NCCDPHP CDC HHS U01 DP000143-01NICHD NIH HHS 5K12HD001255NICHD NIH HHS K12 HD001255NICHD NIH HHS R01 HD034543NICHD NIH HHS R01 HD34543NICHD NIH HHS T32 HD046377
6 · The paper itself

Abstract

objectiveThe purpose of this study was to describe relations among maternal demographic and lifestyle characteristics and midpregnancy levels of angiogenic markers (soluble Fms-like tyrosine kinase-1, placental growth factor, soluble endoglin). STUDY

designIn a large pregnancy cohort, linear models were used to evaluate relations among maternal characteristics and midpregnancy angiogenic markers with and without covariate adjustment. Associations were examined in a subcohort that included term and preterm deliveries (n = 1302) and among "normal" term pregnancies (n = 668).

resultsConcentrations of all factors declined with increasing maternal body mass index. Multiparous women had lower soluble Fms-like tyrosine kinase-1 levels than primiparous women. Higher placental growth factor and slightly lower soluble endoglin levels were observed among women who smoked at enrollment, but not among those women who quit before enrollment. African American women had higher levels of all markers.

conclusionUnderstanding relations among maternal characteristics and levels of angiogenic factors may improve studies that use these markers to examine etiology and/or to predict adverse pregnancy outcome.

Indexed as

Life StyleSmokingAdultAngiogenesis Inducing AgentsAnthropometryAntigens, CDBiomarkersEndoglinFemaleHumansPlacenta Growth FactorPregnancyPregnancy OutcomePregnancy ProteinsPregnancy Trimester, SecondReceptors, Cell SurfaceAngiogenesis Inducing AgentsAntigens, CDBiomarkersEndoglinENG protein, humanFLT1 protein, humanPGF protein, humanPlacenta Growth FactorPregnancy ProteinsReceptors, Cell SurfaceVascular Endothelial Growth Factor Receptor-1

Identifiers

PMID21145529
PMCPMC3079927
OpenAlexW1980160681

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.