ArticleDevelopmental cell2010
Insulin/FOXO signaling regulates ovarian prostaglandins critical for reproduction.
Article in Developmental cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 98 citations in OpenAlex.
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- A germline-to-soma signal triggers an age-related decline of mitochondrial stress response.Nature communications · 2024Article
- Phenomenon of reproductive plasticity in ants.Current opinion in insect science · 2024Review
- A mutation in F-actin polymerization factor suppresses the distal arthrogryposis type 5 PIEZO2 pathogenic variant in Caenorhabditis elegans.Development (Cambridge, England) · 2024Article
- Transmembrane protein 120A (TMEM-120A/TACAN) coordinates with PIEZO channel during Caenorhabditis elegans reproductive regulation.G3 (Bethesda, Md.) · 2023Article
- Prostaglandin FProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The serotonin circuit that coordinates germline proliferation and egg laying with other reproductive functions inProceedings. Biological sciences · 2022Article
- Sperm-Guiding Unconventional Prostaglandins inMetabolites · 2021Review
- Elucidating the Possible Role of FoxO in Depression.Neurochemical research · 2021Review
- Mechanisms of TGFß in prostaglandin synthesis and sperm guidance in Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Review
- The molecular tug of war between immunity and fertility: Emergence of conserved signaling pathways and regulatory mechanisms.BioEssays : news and reviews in molecular, cellular and developmental biology · 2020Review
- Signature profile of cyclooxygenase-independent F2 series prostaglandins in C. elegans and their role in sperm motility.Scientific reports · 2019Article
- Measuring Sperm Guidance and Motility within the Caenorhabditis elegans Hermaphrodite Reproductive Tract.Journal of visualized experiments : JoVE · 2019Article
- The Nematode Caenorhabditis elegans as a Model Organism to Study Metabolic Effects of ω-3 Polyunsaturated Fatty Acids in Obesity.Advances in nutrition (Bethesda, Md.) · 2019Review
- Vitellogenins - Yolk Gene Function and Regulation inFrontiers in physiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Abnormalities in insulin/IGF-1 signaling are associated with infertility, but the molecular mechanisms are not well understood. Here we use liquid chromatography with electrospray ionization tandem mass spectrometry to show that the C. elegans insulin/FOXO pathway regulates the metabolism of locally acting lipid hormones called prostaglandins. C. elegans prostaglandins are synthesized without prostaglandin G/H synthase homologs, the targets of nonsteroidal anti-inflammatory drugs. Our results support the model that insulin signaling promotes the conversion of oocyte polyunsaturated fatty acids (PUFAs) into F-series prostaglandins that guide sperm to the fertilization site. Reduction in insulin signaling activates DAF-16/FOXO, which represses the transcription of germline and intestinal genes required to deliver PUFAs to oocytes in lipoprotein complexes. Nutritional and neuroendocrine cues target this mechanism to control prostaglandin metabolism and reproductive output. Prostaglandins may be conserved sperm guidance factors and widespread downstream effectors of insulin actions that influence both reproductive and nonreproductive processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.