Evidence map›Paper›PMID 21145455›Full record

ReviewCell2010

Membrane budding.

James H Hurley, Evzen Boura, Lars-Anders Carlson, Bartosz Różycki

Open access · bronzeAbstract readReview
In one paragraph

Review in Cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed
39.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 274 citations in OpenAlex.

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  12. Biophysical modeling of membrane curvature generation and curvature sensing by the glycocalyx.Proceedings of the National Academy of Sciences of the United States of America · 2025
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

James H HurleyLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0580, USA. hurley@helix.nih.gov
Evzen Boura
Lars-Anders Carlson
Bartosz Różycki
National Institute of Diabetes and Digestive and Kidney Diseases · USNational Institutes of Health · US

Funding

Cargo Sorting and Intralumenal Vesicle Budding by the ESCRT ComplexesZIADK036123 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HURLEY, JAMES · 2009 to 2013
$2.6M
Structural Studies of Alix and ESCRT Complexes in HIV-1 BuddingZIADK036125 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HURLEY, JAMES · 2009 to 2013
$2.6M
Molecular Recognition by Clathrin AdaptorsZIADK036130 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HURLEY, JAMES · 2009 to 2013
$1.3M
Intramural NIH HHS ZIA DK036123Intramural NIH HHS ZIA DK036125Intramural NIH HHS ZIA DK036130
6 · The paper itself

Abstract

Membrane budding is a key step in vesicular transport, multivesicular body biogenesis, and enveloped virus release. These events range from those that are primarily protein driven, such as the formation of coated vesicles, to those that are primarily lipid driven, such as microdomain-dependent biogenesis of multivesicular bodies. Other types of budding reside in the middle of this spectrum, including caveolae biogenesis, HIV-1 budding, and ESCRT-catalyzed multivesicular body formation. Some of these latter events involve budding away from cytosol, and this unusual topology involves unique mechanisms. This Review discusses progress toward understanding the structural and energetic bases of these different membrane-budding paradigms.

Indexed as

AnimalsCell Membrane StructuresCytoplasmic VesiclesEndosomal Sorting Complexes Required for TransportEukaryotic CellsHumansEndosomal Sorting Complexes Required for Transport

Identifiers

PMID21145455
PMCPMC3102176
OpenAlexW4211044441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.