Insulin signaling: inositol phosphates get into the Akt.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

1. Towards Improved Bioavailability of Cereal Inositol Phosphates,Molecules (Basel, Switzerland) · 2025
   Review
2. An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.eLife · 2023
   Article
3. The Role of Inositol Hexakisphosphate Kinase in the Central Nervous System.Biomolecules · 2023
   Review
4. Urine myo-inositol as a novel prognostic biomarker for diabetic kidney disease: a targeted metabolomics study using nuclear magnetic resonance.Kidney research and clinical practice · 2023
   Article
5. PI3K-AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds.Biomolecules · 2023
   Review
6. Insulin Signal Transduction Perturbations in Insulin Resistance.International journal of molecular sciences · 2021
   Review
7. Role of Inositols and Inositol Phosphates in Energy Metabolism.Molecules (Basel, Switzerland) · 2020
   Review
8. Differential Diabetogenic Effect of Pitavastatin and Rosuvastatin, in vitro and in vivo.Journal of atherosclerosis and thrombosis · 2020
   Article
9. Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases.Molecules (Basel, Switzerland) · 2020
   Review
10. The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle.Frontiers in nutrition · 2019
    Review
11. MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes.International journal of molecular sciences · 2018
    Review
12. The inositol pyrophosphate pathway in health and diseases.Biological reviews of the Cambridge Philosophical Society · 2018
    Review
13. Preliminary Evidence for Adipocytokine Signals in Skeletal Muscle Glucose Uptake.Frontiers in endocrinology · 2018
    Article
14. Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
15. Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes.Frontiers in immunology · 2015
    Review
16. Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2014
    Review
17. High-mobility group A1 proteins enhance the expression of the oncogenic miR-222 in lung cancer cells.Molecular and cellular biochemistry · 2011
    Article

Corrections and comments

• Comment on
  Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.2010

Authors and funding

1 author at 1 institution in 1 country.

Funding

Abstract