ArticlePsychiatry research2011
Abnormalities of the corpus callosum in non-psychotic high-risk offspring of schizophrenia patients.
Article in Psychiatry research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural connectivity associated with familial risk for mental illness: A meta-analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders.Human brain mapping · 2022Pooled it
- Heritable anisotropy associated with cognitive impairments among patients with schizophrenia and their non-psychotic relatives in multiplex families.Psychological medicine · 2022Article
- Multimodal Magnetic Resonance Imaging Reveals Aberrant Brain Age Trajectory During Youth in Schizophrenia Patients.Frontiers in aging neuroscience · 2022Article
- Risk of lead exposure, subcortical brain structure, and cognition in a large cohort of 9- to 10-year-old children.PloS one · 2021Article
- Brain structure, IQ, and psychopathology in young offspring of patients with schizophrenia or bipolar disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Diffusion abnormalities in the corpus callosum in first episode schizophrenia: Associated with enlarged lateral ventricles and symptomatology.Psychiatry research · 2019Article
- Rare case of glioblastoma multiforme located in posterior corpus callosum presenting with depressive symptoms and visual memory deficits.BMJ case reports · 2016Article
- Enlarged lateral ventricles inversely correlate with reduced corpus callosum central volume in first episode schizophrenia: association with functional measures.Brain imaging and behavior · 2016Article
- Callosal Abnormalities Across the Psychosis Dimension: Bipolar Schizophrenia Network on Intermediate Phenotypes.Biological psychiatry · 2016Article
- Diffusion tensor imaging in first degree relatives of schizophrenia and bipolar disorder patients.Schizophrenia research · 2015Review
- A comparison of FreeSurfer-generated data with and without manual intervention.Frontiers in neuroscience · 2015Article
- Genetic markers of white matter integrity in schizophrenia revealed by parallel ICA.Frontiers in human neuroscience · 2015Article
- Brain size, sex, and the aging brain.Human brain mapping · 2015Article
- White matter abnormalities in schizophrenia and schizotypal personality disorder.Schizophrenia bulletin · 2015Article
- Absence of anatomic corpus callosal abnormalities in childhood-onset schizophrenia patients and healthy siblings.Psychiatry research · 2013Article
- Alterations in the cerebral white matter of genetic high risk offspring of patients with schizophrenia spectrum disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2013Article
- Brain-wide functional inter-hemispheric disconnection is a potential biomarker for schizophrenia and distinguishes it from depression.NeuroImage. Clinical · 2013Article
- Alterations in brain structures underlying language function in young adults at high familial risk for schizophrenia.Schizophrenia research · 2012Article
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7 authors.
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Abstract
Alterations in the structure of the corpus callosum (CC) have been observed in schizophrenia. Offspring of schizophrenia parents have 10-15 times higher risk for developing schizophrenia. We examined CC volume in offspring at genetic high-risk (HR) subjects. Since the sub-regions of the CC are topographically mapped to cortical brain regions, we hypothesized that HR subjects may show a decrement in total volume and differential volume decreases in sub-regions of the CC. The offspring of schizophrenia parents (HR; n=70; 36 males) and healthy volunteers with no family or personal history of psychotic disorders (healthy controls (HC); n=73; 37 males) matched for age, gender and education were selected for the study. Magnetic resonance images were collected using a GE 1.5 T scanner and processed using FreeSurfer image analysis software. The CC was divided into five neuroanatomically based partitions. The volume of total CC and the five sub-regions were measured blind to clinical information. With covariation for intracranial volume, HR subjects had significantly reduced total CC, more prominently observed in the anterior splenium. An age-related increase in CC volume was found in the anterior and posterior splenium of healthy controls but not in HR subjects. The volume reduction was greater in male than female HR subjects. The volume reduction in the CC may reflect a reduction in axonal fibers crossing the hemispheres and/or myelination between the left and right temporo-parietal cortices. The absence of an age-related volume increase suggests an abnormal developmental trajectory that may underlie susceptibility to schizophrenia.
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