ArticlePlacenta2011
Proteomic analysis of human serum for finding pathogenic factors and potential biomarkers in preeclampsia.
Article in Placenta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- A review of omics approaches to study preeclampsia.Placenta · 2020Pooled it
- Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration.Human reproduction (Oxford, England) · 2015Pooled it
- Trial
- Complement factor B activation in patients with preeclampsia.Journal of reproductive immunology · 2015Trial
- Serum transthyretin combined with first trimester uterine artery doppler ultrasound for preeclampsia prediction in singleton pregnancies: a prospective observational study.Scientific reports · 2026Observational
- The Coordinated Changes in Platelet Glycan Patterns with Blood Serotonin and Exosomes.International journal of molecular sciences · 2024Review
- First-Trimester Preeclampsia-Induced Disturbance in Maternal Blood Serum Proteome: A Pilot Study.International journal of molecular sciences · 2024Article
- Plasma fibulin-1 levels during pregnancy and delivery: a longitudinal observational study.BMC pregnancy and childbirth · 2021Observational
- Complement and coagulation cascades activation is the main pathophysiological pathway in early-onset severe preeclampsia revealed by maternal proteomics.Scientific reports · 2021Article
- Quantitative proteomics-based analyses performed on pre-eclampsia samples in the 2004-2020 period: a systematic review.Clinical proteomics · 2021Review
- Differential processing of high-molecular-weight kininogen during normal pregnancy.Rapid communications in mass spectrometry : RCM · 2020Article
- RBP4 regulates trophoblastic cell proliferation and invasion via the PI3K/AKT signaling pathway.Molecular medicine reports · 2018Article
- Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia.Frontiers in immunology · 2018Article
- MicroRNA regulation of Transthyretin in trophoblast differentiation and Intra-Uterine Growth Restriction.Scientific reports · 2017Article
- Transthyretin regulates the migration and invasion of JEG-3 cells.Oncology letters · 2017Article
- Mass spectrometry-based proteomics for pre-eclampsia and preterm birth.International journal of molecular sciences · 2015Review
- Protein expression profiles characterize distinct features of mouse cerebral cortices at different developmental stages.PloS one · 2015Article
- Prediction of preeclampsia-bench to bedside.Current hypertension reports · 2014Review
- Article
- Transthyretin as a novel candidate biomarker for preeclampsia.Experimental and therapeutic medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
OBJECTIVE(S): To apply a novel proteomic method to discover potential pathogenic factors and biomarkers of preeclampsia. STUDY
designSera from five patients complicated with preeclampsia and five healthy pregnant controls were separately pooled. Each pool was treated with peptide ligand library beads (PLLBs) to remove high abundance proteins by affinity and thus enrich low abundance proteins. The proteins from the eluate were analyzed by a combination of 1D Gel-LC-MS/MS. Protein expression levels were quantified using spectral counts and the extracted ion current.
results1172 unique proteins in preeclampsia and 1149 in healthy controls were identified in the present study. 51 proteins were differentially expressed between preeclampsia and healthy pregnant women including chorionic somatommammptropin hormone (CSH) and fibulin-1. 31 proteins identified were up-regulated and 20 were down-regulated.
conclusionsThe results demonstrate that peptide ligand library combining with 1D gel-LC-MS/MS analysis is an efficient method to identify differentially expressed proteins in sera and two biological processes of complement and coagulation activations and lipid metabolism were involved in the pathogenesis of preeclampsia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.