ArticleNeuron2010
Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
Article in Neuron, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 113 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
113 citing papers in PubMed, 1 synthesis or guideline pooled it, 185 citations in OpenAlex.
- A Systematic Review of the Role of Gummosin in Improving Memory in the Scopolamine Impaired Memory Model.Archives of Razi Institute · 2024Pooled it
- M1 muscarinic receptor modulation drives sex-specific alterations of Alzheimer's pathophysiology in APPswe/PSEN1ΔE9 mice.The Journal of pharmacology and experimental therapeutics · 2026Article
- Involvement of autoantibodies against G protein-coupled receptors in post-COVID condition and Chronic Fatigue Syndrome.Scientific reports · 2026Article
- Navigating uncertainty: reward location variability induces reorganization of hippocampal spatial representations.bioRxiv : the preprint server for biology · 2025Article
- Acetylcholine in the hippocampus: problems and achievements.Frontiers in neural circuits · 2025Review
- Current Findings and Potential Mechanisms of KarXT (Xanomeline-Trospium) in Schizophrenia Treatment.Clinical drug investigation · 2024Review
- The small conductance CaNeuropharmacology · 2024Article
- Hippocampal-dependent navigation in head-fixed mice using a floating real-world environment.Scientific reports · 2024Article
- Neural ensembles: role of intrinsic excitability and its plasticity.Frontiers in cellular neuroscience · 2024Review
- Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability.Nature communications · 2023Article
- The Induction of Long-Term Potentiation by Medial Septum Activation under Urethane Anesthesia Can Alter Gene Expression in the Hippocampus.International journal of molecular sciences · 2023Article
- Article
- Adaptive control of synaptic plasticity integrates micro- and macroscopic network function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids.International journal of molecular sciences · 2022Review
- A synaptic signal for novelty processing in the hippocampus.Nature communications · 2022Article
- Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Acetylcholine Boosts Dendritic NMDA Spikes in a CA3 Pyramidal Neuron Model.Neuroscience · 2022Article
- Synaptic Input and ACh Modulation Regulate Dendritic CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits.PLoS computational biology · 2021Article
- Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits.Nature communications · 2021Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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- Erratum issued
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Muscarinic receptor activation facilitates the induction of synaptic plasticity and enhances cognitive function. However, the specific muscarinic receptor subtype involved and the critical intracellular signaling pathways engaged have remained controversial. Here, we show that the recently discovered highly selective allosteric M(1) receptor agonist 77-LH-28-1 facilitates long-term potentiation (LTP) induced by theta burst stimulation at Schaffer collateral synapses in the hippocampus. Similarly, release of acetylcholine by stimulation of cholinergic fibers facilitates LTP via activation of M(1) receptors. N-methyl-D-aspartate receptor (NMDAR) opening during theta burst stimulation was enhanced by M(1) receptor activation, indicating this is the mechanism for LTP facilitation. M(1) receptors were found to enhance NMDAR activation by inhibiting SK channels that otherwise act to hyperpolarize postsynaptic spines and inhibit NMDAR opening. Thus, we describe a mechanism where M(1) receptor activation inhibits SK channels, allowing enhanced NMDAR activity and leading to a facilitation of LTP induction in the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.