Evidence map›Paper›PMID 21144994›Full record

ArticleNeuron2010

Unloading intracellular calcium stores reveals regionally specific functions.

Stefan Schmidt, Barbara E Ehrlich

Abstract readComment
In one paragraph

Article in Neuron, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Stefan SchmidtDepartment of Cardiology and Pneumology, University of Goettingen, 37075 Goettingen, Germany.
Barbara E Ehrlich

Funding

Translational CoreP01DK057751 · NIDDK · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2001 to 2020
$25.6M
Regulation of cholangiocytes by InsP3 receptor isoformsR01DK061747 · NIDDK · YALE UNIVERSITY · PI EHRLICH, BARBARA E., NATHANSON, MICHAEL H · 2003 to 2012
$3.4M
NIDDK NIH HHS P01 DK057751NIDDK NIH HHS R01 DK061747
6 · The paper itself

Abstract

Neuronal excitability can be modulated by release of intracellular calcium but the impact of calcium store depletion on intrinsic neuronal properties is unknown. In this issue of Neuron, Narayanan et al. describe an intrinsic plasticity that is depletion induced, is regionally restricted, and may protect neurons from pathological alterations in calcium signaling.

Identifiers

PMID21144994
PMCPMC3031084

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.