Evidence map›Paper›PMID 21144860›Full record

ReviewNeuroscience and biobehavioral reviews2011

Functional connectivity and cholinergic modulation in auditory cortex.

Raju Metherate

Abstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Cholinergic modulation in the vertebrate auditory pathway.Frontiers in cellular neuroscience · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Endogenous Cholinergic Signaling Modulates Sound-Evoked Responses of the Medial Nucleus of the Trapezoid Body.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Nicotinic Receptor Subunit Distribution in Auditory Cortex: Impact of Aging on Receptor Number and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  15. Article
  16. Adenosine AAnatomical record (Hoboken, N.J. : 2007) · 2018
    Article
  17. Donepezil enhances understanding of degraded speech in Alzheimer's disease.Annals of clinical and translational neurology · 2017
    Article
  18. Review
  19. Auditory thalamic circuits and GABAHearing research · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Raju MetherateDepartment of Neurobiology and Behavior, Center for Hearing Research, University of California-Irvine, CA 92697-4550, United States. raju.metherate@uci.edu

Funding

UC Irvine Core Center for Hearing and Communication ResearchP30DC008369 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI METHERATE, RAJU · 2007 to 2016
$3.3M
FUNCTIONS OF NICOTINE RECEPTORS IN SENSORY NEOCORTEXR01DA012929 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI METHERATE, RAJU · 2000 to 2012
$2.4M
Cellular Mechanisms of Aditory Cortex FunctionR01DC002967 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI METHERATE, RAJU · 2003 to 2007
$913k
CELLULAR STUDY OF AUDITORY CORTEX FUNCTIONR29DC002967 · NIDCD · UNIVERSITY OF CALIFORNIA IRVINE · PI METHERATE, RAJU · 1997 to 2001
$226k
CELLULAR MECHANISMS OF AUDITORY CORTEX FUNCTIONR55DC002967 · NIDCD · UNIVERSITY OF CALIFORNIA IRVINE · PI METHERATE, RAJU · 1996 to 1996
–
NIDA NIH HHS DA12929NIDA NIH HHS R01 DA012929NIDCD NIH HHS DC02967NIDCD NIH HHS P30 DC008369NIDCD NIH HHS R01 DC002967NIDCD NIH HHS R29 DC002967
6 · The paper itself

Abstract

Although it is known that primary auditory cortex (A1) contributes to the processing and perception of sound, its precise functions and the underlying mechanisms are not well understood. Recent studies point to a remarkably broad spectral range of largely subthreshold inputs to individual neurons in A1--seemingly encompassing, in some cases, the entire audible spectrum--as evidence for potential, and potentially unique, cortical functions. We have proposed a general mechanism for spectral integration by which information converges on neurons in A1 via a combination of thalamocortical pathways and intracortical long-distance, "horizontal", pathways. Here, this proposal is briefly reviewed and updated with results from multiple laboratories. Since spectral integration in A1 is dynamically regulated, we also show how one regulatory mechanism--modulation by the neurotransmitter acetylcholine (ACh)--could act within the hypothesized framework to alter integration in single neurons. The results of these studies promote a cellular understanding of information processing in A1.

Indexed as

AnimalsAuditory CortexAuditory PathwaysCholinergic AgonistsCholinergic AntagonistsCholinergic NeuronsHumansModels, NeurologicalThalamusCholinergic AgonistsCholinergic Antagonists

Identifiers

PMID21144860
PMCPMC3139107

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.