ArticleDevelopmental biology2011
Interactions between oligodendrocyte precursors control the onset of CNS myelination.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- EGF signaling promotes the lineage conversion of astrocytes into oligodendrocytes.Molecular medicine (Cambridge, Mass.) · 2022Article
- Review
- Oligodendrocyte lineage cells and depression.Molecular psychiatry · 2021Review
- Function of B-Cell CLL/Lymphoma 11B in Glial Progenitor Proliferation and Oligodendrocyte Maturation.Frontiers in molecular neuroscience · 2018Article
- Differential Regulation of MeCP2 Phosphorylation by Laminin in Oligodendrocytes.Journal of molecular neuroscience : MN · 2017Article
- A Novel Approach for Amplification and Purification of Mouse Oligodendrocyte Progenitor Cells.Frontiers in cellular neuroscience · 2016Article
- Article
- Regulation of human glia by multiple sclerosis disease modifying therapies.Seminars in immunopathology · 2015Review
- Bisphenol-A impairs myelination potential during development in the hippocampus of the rat brain.Molecular neurobiology · 2015Article
- Preclinical Models of Encephalopathy of Prematurity.Developmental neuroscience · 2015Review
- Sonic hedgehog and neurotrophin-3 increase oligodendrocyte numbers and myelination after spinal cord injury.Integrative biology : quantitative biosciences from nano to macro · 2014Article
- Connexins-mediated glia networking impacts myelination and remyelination in the central nervous system.Molecular neurobiology · 2014Review
- Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-α inhibitors.Molecular neurobiology · 2014Article
- Article
- Demyelination initiated by oligodendrocyte apoptosis through enhancing endoplasmic reticulum-mitochondria interactions and Id2 expression after compressed spinal cord injury in rats.CNS neuroscience & therapeutics · 2014Article
- Myelin management by the 18.5-kDa and 21.5-kDa classic myelin basic protein isoforms.Journal of neurochemistry · 2013Review
- A rapid and reproducible assay for modeling myelination by oligodendrocytes using engineered nanofibers.Nature protocols · 2013Article
- Apoptosis of oligodendrocytes in the central nervous system results in rapid focal demyelination.Annals of neurology · 2012Article
- Neuron-oligodendrocyte myelination co-culture derived from embryonic rat spinal cord and cerebral cortex.Brain and behavior · 2012Article
- An organotypic slice culture model of chronic white matter injury with maturation arrest of oligodendrocyte progenitors.Molecular neurodegeneration · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The formation of CNS myelin is dependent on the differentiation of oligodendrocyte precursor cells (OPCs) and oligodendrocyte maturation. How the initiation of myelination is regulated is unclear, but it is likely to depend on the development of competence by oligodendrocytes and receptivity by target axons. Here we identify an additional level of control of oligodendrocyte maturation mediated by interactions between the different cellular components of the oligodendrocyte lineage. During development oligodendrocyte precursors mature through a series of stages defined by labeling with monoclonal antibodies A2B5 and O4. Newly differentiated oligodendrocytes begin to express galactocerebroside recognized by O1 antibodies and subsequently mature to myelin basic protein (MBP)-positive cells prior to formation of compact myelin. Using an in vitro brain slice culture system that supports robust myelination, the consequences of ablating cells at different stages of the oligodendrocyte lineage on myelination have been assayed. Elimination of all OPC lineage cells through A2B5+, O4+, and O1+ complement-mediated cell lysis resulted in a delay in development of MBP cells and myelination. Selective elimination of early OPCs (A2B5+) also unexpectedly resulted in delayed MBP expression compared to controls suggesting that early OPCs contribute to the timing of myelination onset. By contrast, elimination of differentiated (O1+) immature oligodendrocytes permanently inhibited the appearance of MBP+ cells suggesting that oligodendrocytes are critical to facilitate the maturation of OPCs. These data illuminate that the presence of intra-lineage feed-forward and feedback cues are important for timely myelination by oligodendrocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.