ArticleBiomaterials2011
The significance of pore microarchitecture in a multi-layered elastomeric scaffold for contractile cardiac muscle constructs.
Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Advances in melt electrowriting for cardiovascular applications.Frontiers in bioengineering and biotechnology · 2024Review
- Elastomeric Polyesters in Cardiovascular Tissue Engineering and Organs-on-a-Chip.Biomacromolecules · 2023Review
- Strategies for Development of Synthetic Heart Valve Tissue Engineering Scaffolds.Progress in materials science · 2023Article
- Polyglycerol Hyperbranched Polyesters: Synthesis, Properties and Pharmaceutical and Biomedical Applications.International journal of molecular sciences · 2019Review
- Digital Design and Automated Fabrication of Bespoke Collagen Microfiber Scaffolds.Tissue engineering. Part C, Methods · 2019Article
- Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction.Advanced functional materials · 2018Article
- 3D-printed gelatin scaffolds of differing pore geometry modulate hepatocyte function and gene expression.Acta biomaterialia · 2018Article
- 3D Bioprinting for Vascularized Tissue Fabrication.Annals of biomedical engineering · 2017Review
- Multi-Material Tissue Engineering Scaffold with Hierarchical Pore Architecture.Advanced functional materials · 2016Article
- Poly(Limonene Thioether) Scaffold for Tissue Engineering.Advanced healthcare materials · 2016Article
- Strategies and Challenges to Myocardial Replacement Therapy.Stem cells translational medicine · 2016Review
- Biomaterials in myocardial tissue engineering.Journal of tissue engineering and regenerative medicine · 2016Review
- [Research process of the preparation of electrostatic spinning of poly-glycerol sebacate and the application in tissue engineering].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2015Article
- Scalable units for building cardiac tissue.Advanced materials (Deerfield Beach, Fla.) · 2014Article
- The role of tissue engineering and biomaterials in cardiac regenerative medicine.The Canadian journal of cardiology · 2014Review
- Tri-layered elastomeric scaffolds for engineering heart valve leaflets.Biomaterials · 2014Article
- Biomimetic scaffold combined with electrical stimulation and growth factor promotes tissue engineered cardiac development.Experimental cell research · 2014Article
- A biodegradable microvessel scaffold as a framework to enable vascular support of engineered tissues.Biomaterials · 2013Article
- Concise review: Engineering myocardial tissue: the convergence of stem cells biology and tissue engineering technology.Stem cells (Dayton, Ohio) · 2013Review
- 3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture.Advanced materials (Deerfield Beach, Fla.) · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Multi-layered poly(glycerol-sebacate) (PGS) scaffolds with controlled pore microarchitectures were fabricated, combined with heart cells, and cultured with perfusion to engineer contractile cardiac muscle constructs. First, one-layered (1L) scaffolds with accordion-like honeycomb shaped pores and elastomeric mechanical properties were fabricated by laser microablation of PGS membranes. Second, two-layered (2L) scaffolds with fully interconnected three dimensional pore networks were fabricated by oxygen plasma treatment of 1L scaffolds followed by stacking with off-set laminae to produce a tightly bonded composite. Third, heart cells were cultured on scaffolds with or without interstitial perfusion for 7 days. The laser-microablated PGS scaffolds exhibited ultimate tensile strength and strain-to-failure higher than normal adult rat left ventricular myocardium, and effective stiffnesses ranging from 220 to 290 kPa. The 7-day constructs contracted in response to electrical field stimulation. Excitation thresholds were unaffected by scaffold scale up from 1L to 2L. The 2L constructs exhibited reduced apoptosis, increased expression of connexin-43 (Cx-43) and matrix metalloprotease-2 (MMP-2) genes, and increased Cx-43 and cardiac troponin-I proteins when cultured with perfusion as compared to static controls. Together, these findings suggest that multi-layered, microfabricated PGS scaffolds may be applicable to myocardial repair applications requiring mechanical support, cell delivery and active implant contractility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.