Evidence map›Paper›PMID 21144096›Full record

ArticleThe British journal of nutrition2011

Epigallocatechin gallate delays the onset of type 1 diabetes in spontaneous non-obese diabetic mice.

Zhuo Fu, Wei Zhen, Julia Yuskavage, Dongmin Liu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.

  1. Pooled it
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  12. Green tea and metabolic syndrome: A 10-year research update review.Iranian journal of basic medical sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zhuo FuDepartment of Human Nutrition, Foods and Exercise, College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University, 1880 Pratt Drive, Corporate Research Center, Blacksburg, VA 24060, USA.
Wei Zhen
Julia Yuskavage
Dongmin Liu
Virginia Tech · US

Funding

Genistein for the Prevention and Treatment of Diabetic Vascular InflammationR21AT004694 · NCCIH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LIU, DONGMIN · 2008 to 2009
$649k
Genistein and cAMP signaling in vascular endotheliumR21AT002739 · NCCIH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LIU, DONGMIN · 2007 to 2008
$434k
NCCIH NIH HHS R21 AT002739NCCIH NIH HHS R21 AT004694
6 · The paper itself

Abstract

Type 1 diabetes (T1D) results from the autoimmune-mediated destruction of pancreatic β-cells, leading to deficiency of insulin production. Successful islet transplantation can normalise hyperglycaemia in T1D patients; however, the limited availability of the islets, loss of islet cell mass through apoptosis after islet isolation and potential autoimmune destruction of the transplanted islets prevent the widespread use of this procedure. Therefore, the search for novel and cost-effective agents that can prevent or treat T1D is extremely important to decrease the burden of morbidity from this disease. In the present study, we discovered that ( - )-epigallocatechin gallate (EGCG, 0·05 % in drinking-water), the primary polyphenolic component in green tea, effectively delayed the onset of T1D in non-obese diabetic (NOD) mice. At 32 weeks of age, eight (66·7 %) out of twelve mice in the control group developed diabetes, whereas only three (25 %) out of twelve mice in the EGCG-treated group became diabetic (P < 0·05). Consistently, mice supplemented with EGCG had significantly higher plasma insulin levels and survival rate but lower glycosylated Hb concentrations compared with the control animals. EGCG had no significant effects on food or water intake and body weight in mice, suggesting that the glucose-lowering effect was not due to an alteration in these parameters. While EGCG did not modulate insulitis, it elevated the circulating anti-inflammatory cytokine IL-10 level in NOD mice. These findings demonstrate that EGCG may be a novel, plant-derived compound capable of reducing the risk of T1D.

Indexed as

AnimalsApoptosisCaspase 3CatechinCell SurvivalDiabetes Mellitus, Type 1Dietary SupplementsFemaleGlycated HemoglobinHumansHypoglycemic AgentsInsulinInterleukin-10Interleukin-12Islets of LangerhansMiceCasp3 protein, mouseCaspase 3Catechinepigallocatechin gallateGlycated HemoglobinHypoglycemic AgentsIL10 protein, mouseInsulinInterleukin-10Interleukin-12

Identifiers

PMID21144096
PMCPMC4335671
OpenAlexW2153587608

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.