ArticleBMC infectious diseases2010
Fusidic acid and clindamycin resistance in community-associated, methicillin-resistant Staphylococcus aureus infections in children of Central Greece.
Article in BMC infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Methicillin-ResistantToxins · 2020Pooled it
- NVC-422 topical gel for the treatment of impetigo.International journal of clinical and experimental pathology · 2011Trial
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- Clinical Features and Antibiotic Susceptibility ofJournal of clinical medicine · 2025Article
- Fusidic Acid Resistance Determinants in Methicillin-Resistant Staphylococcus aureus Isolated in Kuwait Hospitals.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2021Article
- Intolerable Burden of Impetigo in Endemic Settings: A Review of the Current State of Play and Future Directions for Alternative Treatments.Antibiotics (Basel, Switzerland) · 2020Review
- Decolonization ofPostepy dermatologii i alergologii · 2017Article
- Methicillin ResistantFrontiers in microbiology · 2017Article
- Origin and evolution of European community-acquired methicillin-resistant Staphylococcus aureus.mBio · 2014Article
- Prevalence and molecular epidemiology of methicillin-resistant Staphylococcus aureus in a tertiary Greek hospital.Hippokratia · 2014Article
- A new strategy to fight antimicrobial resistance: the revival of old antibiotics.Frontiers in microbiology · 2014Review
- Investigational antimicrobial agents of 2013.Clinical microbiology reviews · 2013Review
- European ST80 community-associated methicillin-resistant Staphylococcus aureus orbital cellulitis in a neonate.BMC ophthalmology · 2012Article
- Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistance.FEMS microbiology reviews · 2011Review
- A study of community-associated methicillin-resistant Staphylococcus aureus in patients with pyoderma.Indian dermatology online journalArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn Greece, fusidic acid and clindamycin are commonly used for the empiric therapy of suspected staphylococcal infections.
methodsThe medical records of children examined at the outpatient clinics or admitted to the pediatric wards of the University General Hospital of Larissa, Central Greece, with community-associated staphylococcal infections from January 2003 to December 2009 were reviewed.
resultsOf 309 children (0-14 years old), 21 (6.8%) had invasive infections and 288 (93.2%) skin and soft tissue infections (SSTIs). Thirty-five patients were ≤30 days of age. The proportion of staphylococcal infections caused by a community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) isolate increased from 51.5% (69 of 134) in 2003-2006 to 63.4% (111 of 175) in 2007-2009 (P = 0.037). Among the CA-MRSA isolates, 88.9% were resistant to fusidic acid, 77.6% to tetracycline, and 21.1% to clindamycin. Clindamycin resistance increased from 0% (2003) to 31.2% (2009) among the CA-MRSA isolates (P = 0.011). Over the 7-year period, an increase in multidrug-resistant CA-MRSA isolates was observed (P = 0.004). One hundred and thirty-one (93.6%) of the 140 tested MRSA isolates were Panton-Valentine leukocidin-positive. Multilocus sequence typing of 72 CA-MRSA isolates revealed that they belonged to ST80 (n = 61), ST30 (n = 6), ST377 (n = 3), ST22 (n = 1), and ST152 (n = 1). Resistance to fusidic acid was observed in ST80 (58/61), ST30 (1/6), and ST22 (1/1) isolates.
conclusionIn areas with high rate of infections caused by multidrug-resistant CA-MRSA isolates, predominantly belonging to the European ST80 clone, fusidic acid and clindamycin should be used cautiously as empiric therapy in patients with suspected severe staphylococcal infections.
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