ArticleBMC developmental biology2010
Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish.
Article in BMC developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Kmo restricts Salmonella in a whole organism infection model by promoting macrophage lysosomal acidification through kainate receptor antagonism.PLoS pathogens · 2025Article
- 3-Hydroxykynurenine targets kainate receptors to promote defense against infection.Nature chemical biology · 2024Article
- The H3K27 demethylase controls the lateral line embryogenesis of zebrafish.Cell biology and toxicology · 2023Article
- Peripheral nerve development in zebrafish requires muscle patterning by tcf15/paraxis.Developmental biology · 2022Article
- Tetraspanin Cd9b and Cxcl12a/Cxcr4b have a synergistic effect on the control of collective cell migration.PloS one · 2021Article
- Mib1 contributes to persistent directional cell migration by regulating the Ctnnd1-Rac1 pathway.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Zebrafish aversive taste co-receptor is expressed in both chemo- and mechanosensory cells and plays a role in lateral line development.Scientific reports · 2017Article
- Article
- Review
- Identification of sensory hair-cell transcripts by thiouracil-tagging in zebrafish.BMC genomics · 2015Article
- Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion.Disease models & mechanisms · 2015Article
- Gene-expression analysis of hair cell regeneration in the zebrafish lateral line.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Dynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Gβ1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium.Developmental biology · 2014Article
- Gene miles-apart is required for formation of otic vesicle and hair cells in zebrafish.Cell death & disease · 2013Article
- Fluorescent activated cell sorting (FACS) combined with gene expression microarrays for transcription enrichment profiling of zebrafish lateral line cells.Methods (San Diego, Calif.) · 2013Article
- Differential transcript isoform usage pre- and post-zygotic genome activation in zebrafish.BMC genomics · 2013Article
- Disappearing scales in carps: re-visiting Kirpichnikov's model on the genetics of scale pattern formation.PloS one · 2013Article
- Article
- Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development.Development (Cambridge, England) · 2011Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundDevelopment of the posterior lateral line (PLL) system in zebrafish involves cell migration, proliferation and differentiation of mechanosensory cells. The PLL forms when cranial placodal cells delaminate and become a coherent, migratory primordium that traverses the length of the fish to form this sensory system. As it migrates, the primordium deposits groups of cells called neuromasts, the specialized organs that contain the mechanosensory hair cells. Therefore the primordium provides both a model for studying collective directional cell migration and the differentiation of sensory cells from multipotent progenitor cells.
resultsThrough the combined use of transgenic fish, Fluorescence Activated Cell Sorting and microarray analysis we identified a repertoire of key genes expressed in the migrating primordium and in differentiated neuromasts. We validated the specific expression in the primordium of a subset of the identified sequences by quantitative RT-PCR, and by in situ hybridization. We also show that interfering with the function of two genes, f11r and cd9b, defects in primordium migration are induced. Finally, pathway construction revealed functional relationships among the genes enriched in the migrating cell population.
conclusionsOur results demonstrate that this is a robust approach to globally analyze tissue-specific expression and we predict that many of the genes identified in this study will show critical functions in developmental events involving collective cell migration and possibly in pathological situations such as tumor metastasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.