ArticleLipids in health and disease2010
Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles.
Article in Lipids in health and disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06869109 (Serum CXCL10 and CRP Levels in Patients With Acne Vulgaris in Correlation With Disease Severity), which is not on this map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serum CXCL10 and CRP Levels in Patients With Acne Vulgaris in Correlation With Disease Severity
Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
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- Lactobacillus-derived extracellular vesicles provide multi-target acne treatment by enriched proteins and skin microbiota protection.Journal of nanobiotechnology · 2026Article
- CircRNA Profiling Identifies hsa_circRNA_003201 Associated with a Predicted NLRX1-Related Regulatory Network in an Acne-Associated Inflammatory Sebocyte Model.Journal of inflammation research · 2026Article
- Emerging Roles of Ferroptosis in Skin Pathophysiology.The Journal of investigative dermatology · 2025Review
- Vitamin D and skin disorders: bridging molecular insights to clinical innovations.Molecular medicine (Cambridge, Mass.) · 2025Review
- Effect of afzelin on inflammation and lipogenesis in particulate matter-stimulatedFrontiers in medicine · 2025Article
- The Predictive Factors of Acne Scarring and Post-Inflammatory Hyperpigmentation: A Retrospective Cohort Study.Clinical, cosmetic and investigational dermatology · 2025Article
- Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin Levels as an Indicator of Oxidative Stress in Acne Vulgaris.Dermatology practical & conceptual · 2023Article
- Oxygen Exposure and Tolerance Shapes the Cell Wall-Associated Lipids of the Skin CommensalMicroorganisms · 2023Article
- Bio-Based Nano-Enabled Cosmetic Formulations for the Treatment ofAntioxidants (Basel, Switzerland) · 2023Article
- Transcriptome Analysis of Particulate Matter 2.5-Induced Abnormal Effects on Human Sebocytes.International journal of molecular sciences · 2022Article
- Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial.Contemporary clinical trials communications · 2021Article
- Association of acne, hirsutism, androgen, anxiety, and depression on cognitive performance in polycystic ovary syndrome: A cross-sectional study.International journal of reproductive biomedicine · 2020Article
- A Correlation between Serum Level of Alkaline Phosphatase and Acne Severity in Children and Adolescents: A Retrospective Cross-Sectional Study.Annals of dermatology · 2020Article
- Evaluating the In Vitro Potential of Natural Extracts to Protect Lipids from Oxidative Damage.Antioxidants (Basel, Switzerland) · 2020Review
- Potential Role of the Microbiome in Acne: A Comprehensive Review.Journal of clinical medicine · 2019Review
- Vitamin D, Adiponectin, Oxidative Stress, Lipid Profile, and Nutrient Intakes in the Females with Acne Vulgaris: A Case-Control Study.Galen medical journal · 2019Article
- Development of new 3D human ex vivo models to study sebaceous gland lipid metabolism and modulations.Cell proliferation · 2019Article
- Edible Plants and Their Influence on the Gut Microbiome and Acne.International journal of molecular sciences · 2017Review
- The effect of probiotics on immune regulation, acne, and photoaging.International journal of women's dermatology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acne vulgaris is a common dermatological disorder, one that is frequently associated with depression, anxiety and other psychological sequelae. In recent years there has been an increasing focus on the extent to which oxidative stress is involved in the pathophysiology of acne. Emerging studies have shown that patients with acne are under increased cutaneous and systemic oxidative stress. Indeed, there are indications that lipid peroxidation itself is a match that lights an inflammatory cascade in acne. The notion that lipid peroxidation is a 'starter gun' in acne is not a new one; here we review the nearly 50-year-old lipid peroxidation theory and provide a historical perspective to the contemporary investigations and clinical implications.In addition, we present a novel hypothesis in which lipid peroxidation may be priming an increased susceptibility to co-morbid depression and anxiety in those with acne. The emerging research on the systemic burden of oxidative stress in acne sheds further light on the brain-skin axis. The recent findings also suggest potential avenues of approach for the treatment of acne via specific nutrients, dietary modifications, oral and topical interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.