ArticleThe European journal of neuroscience2011
Associative learning increases adult neurogenesis during a critical period.
Article in The European journal of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Paternal Deprivation Alters Neural Stem Cells Proliferation and Epigenetic Histone Modifications in the Neurogenic Niches of Adult Prairie Voles.International journal of molecular sciences · 2026Article
- Nutraceuticals: using food to enhance brain health by modulating postnatal neurogenesis in animal models and patient populations.Stem cells translational medicine · 2025Review
- Effect of adult hippocampal neurogenesis on pattern separation and its applications.Cognitive neurodynamics · 2024Article
- Aging Modulates the Ability of Quiescent Radial Glia-Like Stem Cells in the Hippocampal Dentate Gyrus to be Recruited into Division by Pro-neurogenic Stimuli.Molecular neurobiology · 2024Article
- Spatial Learning Promotes Adult Neurogenesis in Specific Regions of the Zebrafish Pallium.Frontiers in cell and developmental biology · 2022Article
- Unexpected Consequences of Noise-Induced Hearing Loss: Impaired Hippocampal Neurogenesis, Memory, and Stress.Frontiers in integrative neuroscience · 2022Review
- The Potential Role of Inflammation in Modulating Endogenous Hippocampal Neurogenesis After Spinal Cord Injury.Frontiers in neuroscience · 2021Review
- Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.PloS one · 2021Article
- Enduring neuroimmunological consequences of developmental experiences: From vulnerability to resilience.Molecular and cellular neurosciences · 2020Review
- Adult-Born Hippocampal Neurons Undergo Extended Development and Are Morphologically Distinct from Neonatally-Born Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Role of BDNF on Neural Plasticity in Depression.Frontiers in cellular neuroscience · 2020Article
- Dentate gyrus neurons that are born at the peak of development, but not before or after, die in adulthood.Brain and behavior · 2019Article
- Hippocampal Mechanisms Underlying Impairment in Spatial Learning Long After Establishment of Noise-Induced Hearing Loss in CBA Mice.Frontiers in systems neuroscience · 2018Article
- Noise induced hearing loss impairs spatial learning/memory and hippocampal neurogenesis in mice.Scientific reports · 2016Article
- MAP training: combining meditation and aerobic exercise reduces depression and rumination while enhancing synchronized brain activity.Translational psychiatry · 2016Article
- Sexual Conspecific Aggressive Response (SCAR): A Model of Sexual Trauma that Disrupts Maternal Learning and Plasticity in the Female Brain.Scientific reports · 2016Article
- Interaction between Neurogenesis and Hippocampal Memory System: New Vistas.Cold Spring Harbor perspectives in biology · 2015Review
- Mental and Physical (MAP) Training: a neurogenesis-inspired intervention that enhances health in humans.Neurobiology of learning and memory · 2014Review
- Hemispheric asymmetry in new neurons in adulthood is associated with vocal learning and auditory memory.PloS one · 2014Article
- Preparing for adulthood: thousands upon thousands of new cells are born in the hippocampus during puberty, and most survive with effortful learning.Frontiers in neuroscience · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Learning increases the number of immature neurons that survive and mature in the adult hippocampus. One-week-old cells are more likely to survive in response to learning than cells in animals that are exposed to training but do not learn. Because neurogenesis is an ongoing and overlapping process, it is possible that learning differentially affects new cells as a function of their maturity. To address this issue, we examined the effects of associative learning on the survival of cells at different stages of development. Training did not alter the number of cells that were produced during the training experience. Cells that were 1-2 weeks of age at the time of training survived after learning but cells that were younger or older did not. In contrast, cells that were produced during training were less likely to survive than cells in untrained animals. Additionally, the number of cells that were generated after learning in trained animals was not different from the number in untrained animals. Finally, survival was not increased if the memory was expressed when the cells were about 1-week-old. Together, these results indicate that new neurons are rescued from death by initial acquisition, not the expression or reacquisition, of an associative memory and only during a critical period. Overall, these results suggest the presence of a feedback system, which controls how many new neurons become incorporated into the adult brain in response to learning.
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Registered trials
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