ArticleAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica2011
Development of gut microbiota in infants not exposed to medical interventions.
Article in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it, 158 citations in OpenAlex.
- Maternal gut microbiota in the postpartum Period: A Systematic review.European journal of obstetrics, gynecology, and reproductive biology · 2023Pooled it
- Early life microbial succession in the gut follows common patterns in humans across the globe.Nature communications · 2025Article
- Malnutrition and Its Influence on Gut sIgA-Microbiota Dynamics.Biomedicines · 2025Review
- Article
- Unraveling the Role of the Human Gut Microbiome in Health and Diseases.Microorganisms · 2024Review
- A rare case of invasiveClinical case reports · 2024Article
- Meconium microbiota in naturally delivered canine puppies.BMC veterinary research · 2024Article
- What Happens in the Gut during the Formation of Neonatal Jaundice-Underhand Manipulation of Gut Microbiota?International journal of molecular sciences · 2024Review
- Exploring the Mechanistic Interplay between Gut Microbiota and Precocious Puberty: A Narrative Review.Microorganisms · 2024Review
- Early gut microbiota intervention in premature infants: Application perspectives.Journal of advanced research · 2023Review
- Review
- The Emergence of Antimicrobial Resistance and Virulence Characteristics inAntibiotics (Basel, Switzerland) · 2023Article
- Determinants of microbial colonization in the premature gut.Molecular medicine (Cambridge, Mass.) · 2023Review
- Development of the gut microbiota during early life in premature and term infants.Gut pathogens · 2023Article
- Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies.Chemical reviews · 2023Review
- Why Are Bifidobacteria Important for Infants?Microorganisms · 2022Review
- Neonatal Programming of Microbiota Composition: A Plausible Idea That Is Not Supported by the Evidence.Frontiers in microbiology · 2022Review
- The interplay between diet, gut microbes, and host epigenetics in health and disease.The Journal of nutritional biochemistry · 2021Review
- Developmental intestinal microbiome alterations in canine fading puppy syndrome: a prospective observational study.NPJ biofilms and microbiomes · 2021Article
- Necrotizing Enterocolitis and the Microbiome: Current Status and Future Directions.The Journal of infectious diseases · 2021Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Knowledge of the composition of a normal healthy gut microbiota during infancy is important for understanding the role of gut microbiota in disease. A limitation of previous studies is that they are based on infants who have been subject to factors, which can have a profound disruptive effect on the natural colonization process. We describe the colonization process, during the first 4 months after birth, in 85 infants who have experienced no major medical or dietary interventions. They were all vaginally delivered, healthy, term infants, who were not exposed to antibiotics, exclusively breastfed during their first month of life and at least partially breastfed up to 4 months. Selected microbial groups were identified by targeting small subunit microbial ribosomal RNA genes. In contrast to more recent studies, but in agreement with older studies, almost all our infants harbored γ-Proteobacteria and Bifidobacterium. Yet undefined non-cultivable species belonging to Bacteroides, as well as microbes identified as Lachnospiraceae 2, were common. Strong associations were observed between some specific constituents of microbiota at day 4 and the concentration of specific microbial groups at day 120, indicating that early gut microbiota may influence later microbiota. Novel information of the undisturbed composition of early gut microbiota in babies is presented.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.