ArticleBritish journal of clinical pharmacology2011
Sex-related differences in hospital admissions attributed to adverse drug reactions in the Netherlands.
Article in British journal of clinical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis.CNS drugs · 2021Pooled it
- Drug-Related Hospital Visits and Admissions Associated with Laboratory or Physiologic Abnormalities-A Systematic-Review.PloS one · 2013Pooled it
- Morphine-induced hepatotoxicity in rats: Sex and dose variations in liver enzymes, oxidative stress, inflammation, apoptosis, and histopathology.Biomolecules & biomedicine · 2026Article
- Sex-based differences in the NRF2 oxidative stress response: Implications for precision therapeutics.Redox biology · 2026Review
- Trends and Patterns of Adverse Drug Reaction Reporting in Sierra Leone: A Retrospective Analysis of VigiFlow Data (2008-2022).Pharmacoepidemiology and drug safety · 2026Article
- Sex-related differences in cardiovascular pharmacotherapy: fiction or fact? Why can't we see the evidence?European heart journal. Cardiovascular pharmacotherapy · 2025Review
- Sex Differences in Electrolyte Disturbances Among Diuretic Users According to Renal Function and Age.Drug safety · 2025Article
- Prediction of adverse drug reactions using demographic and non-clinical drug characteristics in FAERS data.Scientific reports · 2024Article
- Predicting sex differences in the effects of diuretics in renal epithelial transport during angiotensin II-induced hypertension.American journal of physiology. Renal physiology · 2024Article
- Practical solutions for including sex as a biological variable (SABV) in preclinical neuropsychopharmacological research.Journal of neuroscience methods · 2024Review
- Women have a higher risk of hospital admission associated with hyponatremia than men while using diuretics.Frontiers in pharmacology · 2024Article
- Adverse drug reactions in hospitals: population estimates for Portugal and the ICD-9-CM to ICD-10-CM crosswalk.BMC health services research · 2023Article
- Interactions between Gender and Sepsis-Implications for the Future.Microorganisms · 2023Review
- Incidence of severe hypokalaemia in patients taking indapamide.Internal and emergency medicine · 2023Article
- Addressing persistent evidence gaps in cardiovascular sex differences research - the potential of clinical care data.Frontiers in global women's health · 2022Article
- Prevalence and predictors of medication-related emergency department visit in older adults: A multicenter study linking national claim database and hospital medical records.Frontiers in pharmacology · 2022Article
- Adverse drug events leading to emergency department visits: A multicenter observational study in Korea.PloS one · 2022Observational
- Sex differences in hypertension. Do we need a sex-specific guideline?Frontiers in cardiovascular medicine · 2022Review
- Risk of Hospitalization for Adverse Drug Events in Women and Men: A Post Hoc Analysis of an Active Pharmacovigilance Study in Italian Emergency Departments.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Sex differences associated with adverse drug reactions resulting in hospital admissions.Biology of sex differences · 2021Article
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Abstract
what is already known about this subjectWomen are more at risk for developing adverse drug reactions (ADRs) due to differences in pharmacokinetics, pharmacodynamics and drug use. ADRs regularly lead to hospital admissions. WHAT THIS STUDY ADDS: There are differences between the sexes in hospital admissions attributed to ADRs. The risk of being hospitalized with an ADR varies between the sexes in the type of reaction and the causative drug.
aimAdverse drug reactions (ADRs) are a major burden in health care, regularly leading to hospital admission, morbidity or death. Women tend to have a higher risk of adverse drug reactions with a 1.5 to 1.7-fold greater risk than men. Our primary aim was to study differences in ADR-related hospitalizations between the sexes.
methodsWe conducted a nationwide study of all ADR-related hospitalizations in the period between 2000 and 2005 in the Netherlands, which were selected from all 9,287,162 hospital admissions in this period. ADR-drug group combinations with at least 50 admissions in one of the sexes were selected. Relative risks and confidence intervals were calculated with respect to total admissions and total prescriptions with men as reference.
resultsIn total, 0.41% of the 4,236,368 admissions in men (95% CI 0.40, 0.42%) and 0.47% of the 5,050,794 admissions in women (95% CI 0.46, 0.48%) were attributed to an ADR by medical specialists (57% of all ADR-related admissions were in women). Differences between the sexes in risk for ADR-related hospitalization were found for antineoplastic and immunosuppressive drugs, antirheumatics, anticoagulants and salicylates, cardiovascular and neurological drugs, steroids and antibiotics. In certain drug categories, risks for hospitalization changed after taking into account total drug prescriptions.
conclusionIn all different drug classes, significant differences exist between the sexes in ADR-related hospital admissions. Cardiovascular drugs account for the most pronounced differences between men and women. More research is needed to explain the clear sex differences in ADR-related hospital admissions.
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