ArticleAlcoholism, clinical and experimental research2011
Candidate placental biomarkers for intrauterine alcohol exposure.
Article in Alcoholism, clinical and experimental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects.Archives of toxicology · 2026Pooled it
- A comparison of the prevalence of prenatal alcohol exposure obtained via maternal self-reports versus meconium testing: a systematic literature review and meta-analysis.BMC pregnancy and childbirth · 2014Pooled it
- Prenatal alcohol exposure is associated with changes in placental gene co-expression networks.Scientific reports · 2024Article
- The interaction of genetic sex and prenatal alcohol exposure on health across the lifespan.Frontiers in neuroendocrinology · 2023Review
- Article
- Screening for Alcohol Use in Pregnancy: a Review of Current Practices and Perspectives.International journal of mental health and addiction · 2023Article
- Mechanisms underlying microRNA-222-3p modulation of methamphetamine-induced conditioned place preference in the nucleus accumbens in mice.Psychopharmacology · 2022Article
- Transgenerational Abnormalities Induced by Paternal Preconceptual Alcohol Drinking: Findings from Humans and Animal Models.Current neuropharmacology · 2022Review
- Preconception paternal alcohol exposure exerts sex-specific effects on offspring growth and long-term metabolic programming.Epigenetics & chromatin · 2019Article
- Prenatal transportation stress alters genome-wide DNA methylation in suckling Brahman bull calves.Journal of animal science · 2018Article
- The Type 3 Deiodinase: Epigenetic Control of Brain Thyroid Hormone Action and Neurological Function.International journal of molecular sciences · 2018Review
- Thyroid Function in Pregnant Women With Moderate to Severe Alcohol Consumption Is Related to Infant Developmental Outcomes.Frontiers in endocrinology · 2018Article
- Placental Proteomics Reveal Insights into Fetal Alcohol Spectrum Disorders.Alcoholism, clinical and experimental research · 2017Article
- Prenatal alcohol exposure and prenatal stress differentially alter glucocorticoid signaling in the placenta and fetal brain.Neuroscience · 2017Article
- Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Isolating the role of elevated Phlda2 in asymmetric late fetal growth restriction in mice.Disease models & mechanisms · 2014Article
- Low-dose T₃ replacement restores depressed cardiac T₃ levels, preserves coronary microvasculature and attenuates cardiac dysfunction in experimental diabetes mellitus.Molecular medicine (Cambridge, Mass.) · 2014Article
- Maternal and neonatal plasma microRNA biomarkers for fetal alcohol exposure in an ovine model.Alcoholism, clinical and experimental research · 2014Article
- Hypothesis: genetic and epigenetic risk factors interact to modulate vulnerability and resilience to FASD.Frontiers in genetics · 2014Article
- Low-dose thyroxine attenuates autism-associated adverse effects of fetal alcohol in male offspring's social behavior and hippocampal gene expression.Alcoholism, clinical and experimental research · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFetal alcohol spectrum disorder (FASD) is a leading cause of nongenetic mental retardation and other neurodevelopmental deficits. Earlier diagnosis of FASD would greatly improve prognosis for individuals and families affected by this disorder. Here, we identify candidate placental biomarkers in an animal model of FASD that recapitulates many aspects of human FASD.
methodsPregnant Sprague-Dawley (SD) females were assigned to 1 of 3 diet groups on gestation day 8 (G8): Ethanol (E), Pair-fed (PF) or Control (C). E dams received ethanol-containing liquid diet and PF dams received isocaloric liquid diet in an amount that matched the paired E dam's diet consumption the previous day. Control dams received laboratory chow and water ad libitum. Whole placentae from individual fetuses were collected on gestational day 21 (G21) for analyses. Western blotting and quantitative real-time RT-PCR were used to measure protein and mRNA levels of placental iodothyronine deiodinase III (Dio3), thyroid hormone receptor α1 (TRα1), and glucocorticoid receptor (GR). Placental mRNA levels of insulin-like growth factor 2 (Igf-2), pleckstrin homology-like domain family A member 2 (Phlda2), and cyclin-dependent kinase inhibitor 1C (Cdkn1c) were also measured.
resultsPlacental protein and mRNA levels from ethanol (E)-consuming dams showed the following changes: increased Dio3, decreased TRα1, and decreased GR compared to both C and PF dams. Placental mRNA levels of intrauterine growth restriction (IUGR) markers Igf-2, Phlda2, and Cdkn1c were altered similarly in PF and E dams.
conclusionsWe propose the specific pattern of increased Dio3 and decreased TRα1 and GR protein levels in the placenta as selective biomarker for intrauterine alcohol exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.