ArticleTwin research and human genetics : the official journal of the International Society for Twin Studies2010
A commentary on 'common SNPs explain a large proportion of the heritability for human height' by Yang et al. (2010).
Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
126 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.Behavior genetics · 2016Pooled it
- Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.JAMA psychiatry · 2015Pooled it
- Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.Molecular psychiatry · 2014Pooled it
- GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.Science (New York, N.Y.) · 2013Pooled it
- Novel locus including FGF21 is associated with dietary macronutrient intake.Human molecular genetics · 2013Pooled it
- The molecular genetic architecture of self-employment.PloS one · 2013Pooled it
- An assessment of the individual and collective effects of variants on height using twins and a developmentally informative study design.PLoS genetics · 2011Pooled it
- Genome-wide association studies establish that human intelligence is highly heritable and polygenic.Molecular psychiatry · 2011Pooled it
- Trial
- PGS-GS: a framework integrating polygenic scores and genomic selection in animal breeding.Briefings in bioinformatics · 2026Article
- Interpreting SNP heritability in admixed populations.Genetics · 2025Article
- Impact of Selection Signature on Genomic Prediction and Heritability Estimation in Livestock.Animals : an open access journal from MDPI · 2025Article
- Interpreting SNP heritability in admixed populations.bioRxiv : the preprint server for biology · 2025Article
- Effect of breed composition in genomic prediction using crossbred pig reference population.Journal of animal science and technology · 2025Article
- Genomic variance partitioning of carcass and meat quality traits in Angus beef cattle.Frontiers in veterinary science · 2025Article
- Endophenotype 2.0: updated definitions and criteria for endophenotypes of psychiatric disorders, incorporating new technologies and findings.Translational psychiatry · 2024Review
- Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures.G3 (Bethesda, Md.) · 2023Article
- Polygenic risk prediction: why and when out-of-sample prediction RAmerican journal of human genetics · 2023Article
- Serum metabolic profile and metabolome genome-wide association study in chicken.Journal of animal science and biotechnology · 2023Article
- Genomic heritability and correlation between carcass traits in Japanese Black cattle evaluated under different ceilings of relatedness among individuals.Frontiers in genetics · 2023Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
- Comment on
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently a paper authored by ourselves and a number of co-authors about the proportion of phenotypic variation in height that is explained by common SNPs was published in Nature Genetics (Yang et al., 2010). Common SNPs explain a large proportion of the heritability for human height (Yang et al.). During the refereeing process (the paper was rejected by two other journals before publication in Nature Genetics) and following the publication of Yang et al. (2010) it became clear to us that the methodology we applied, the interpretation of the results and the consequences of the findings on the genetic architecture of human height and that for other traits such as complex disease are not well understood or appreciated. Here we explain some of these issues in a style that is different from the primary publication, that is, in the form of a number of comments and questions and answers. We also report a number of additional results that show that the estimates of additive genetic variation are not driven by population structure.
Indexed as
Identifiers
21142928What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.