ArticleInhalation toxicology2010
Inhaled nickel nanoparticles alter vascular reactivity in C57BL/6 mice.
Article in Inhalation toxicology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Micro and nanoplastic inhalation during pregnancy elicits uterine endothelial dysfunction in Sprague Dawley rats by impeding nitric oxide signaling.bioRxiv : the preprint server for biology · 2025Article
- The pulmonary effects of nickel-containing nanoparticles: Cytotoxicity, genotoxicity, carcinogenicity, and their underlying mechanisms.Environmental science. Nano · 2024Article
- Single pulmonary nanopolystyrene exposure in late-stage pregnancy dysregulates maternal and fetal cardiovascular function.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Nicotine and Microvascular Responses in Skeletal Muscle from Acute Exposure to Cigarettes and Vaping.International journal of molecular sciences · 2023Article
- Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats.Particle and fibre toxicology · 2023Article
- Review and Evaluation of the Potential Health Effects of Oxidic Nickel Nanoparticles.Nanomaterials (Basel, Switzerland) · 2021Review
- Acute intravenous exposure to silver nanoparticles during pregnancy induces particle size and vehicle dependent changes in vascular tissue contractility in Sprague Dawley rats.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Metal rich particulate matter impairs acetylcholine-mediated vasorelaxation of microvessels in mice.Particle and fibre toxicology · 2015Article
- Inhalation toxicology methods: the generation and characterization of exposure atmospheres and inhalational exposures.Current protocols in toxicology · 2015Article
- PVP formulated fullerene (C60) increases Rho-kinase dependent vascular tissue contractility in pregnant Sprague Dawley rats.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells.Inhalation toxicology · 2014Article
- C₆₀ exposure augments cardiac ischemia/reperfusion injury and coronary artery contraction in Sprague Dawley rats.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- A synergistic vascular effect of airborne particulate matter and nickel in a mouse model.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- The physiology of cardiovascular disease and innovative liposomal platforms for therapy.International journal of nanomedicine · 2013Review
- Article
- Cadmium associated with inhaled cadmium oxide nanoparticles impacts fetal and neonatal development and growth.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Nickel ENMs activate HIF-1α.Environmental health perspectives · 2011Article
- Changes in cardiopulmonary function induced by nanoparticles.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
- The effect ofInternational journal of immunopathology and pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe use of nanoparticles (NPs) in technological applications is rapidly expanding, but the potential health effects associated with NP exposure are still largely unknown. Given epidemiological evidence indicating an association between inhaled ambient ultrafine particles and increased risk of cardiovascular disease morbidity and mortality, it has been suggested that exposure to NPs via inhalation may induce similar cardiovascular responses.
methodsMale C57BL/6 mice were exposed via whole-body inhalation to either filtered air (FA) or nickel hydroxide (NH) NPs (100, 150, or 900 µg/m(3)) for 1, 3, or 5 consecutive days (5 h/day). At 24-h post-exposure, vascular function in response to a vasoconstrictor, phenylephrine (PE), and a vasodilator, acetylcholine (ACh), was measured in the carotid artery.
resultsCarotid arteries from mice exposed to all concentrations of NH-NPs showed statistically significant differences in graded doses of PE-induced contractile responses compared with those from FA mice. Similarly, vessels from NH-NP-exposed mice also demonstrated impaired vasorelaxation following graded doses of ACh as compared with FA mice.
conclusionsThese results suggest that short-term exposure to NH-NPs can induce acute endothelial disruption and alter vasoconstriction and vasorelaxation. These findings are consistent with other studies assessing vascular tone and function in the aorta, coronary, and mesenteric vessels from mice exposed to motor vehicular exhaust and concentrated ambient particles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.