ArticleJournal of the American Chemical Society2011
Core-clickable PEG-branch-azide bivalent-bottle-brush polymers by ROMP: grafting-through and clicking-to.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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Who cites it
68 citing papers in PubMed.
- Recyclable Graft Polymer Enabled by RAFT Step-Growth Polymerization and Deconstruction.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Antibody-bottlebrush prodrug conjugates for targeted cancer therapy.Nature biotechnology · 2026Article
- Antibody-bottlebrush prodrugs pack a punch for targeted cancer therapy.Nature biotechnology · 2026Article
- Polymer Translocation Through a Nanopore.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Polypept(o)ide Based Biodegradable Cylindrical Polymer Brushes: Controlling Size, Shape, Surface Functionality, and Stability.ACS applied materials & interfaces · 2025Article
- Article
- Straightforward synthesis of complex polymeric architectures with ultra-high chain density.Chemical science · 2024Article
- Comparison of Polypentenamer and Polynorbornene Bottlebrushes in Dilute Solution.ACS polymers Au · 2024Article
- Bottlebrush Networks: A Primer for Advanced Architectures.Angewandte Chemie (International ed. in English) · 2024Review
- Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives.International journal of molecular sciences · 2024Review
- Caspase-3-Responsive, Fluorogenic Bivalent Bottlebrush Polymers.ACS macro letters · 2024Article
- A dual action coumarin-camptothecin polymer for light responsive drug release and photodynamic therapy.Polymer chemistry · 2024Article
- Novel epoxy-terminated macromonomers and their polymerization for synthesis of bottle-brush type amphiphilic block copolymers.RSC advances · 2023Article
- Synthesis of Bottlebrush Polymers byJournal of the American Chemical Society · 2023Article
- Article
- Stimuli-Responsive Boron-Based Materials in Drug Delivery.International journal of molecular sciences · 2023Review
- Review
- A Review of Multi-Material 3D Printing of Functional Materials via Vat Photopolymerization.Polymers · 2022Review
- Topologically Precise and Discrete Bottlebrush Polymers: Synthesis, Characterization, and Structure-Property Relationships.JACS Au · 2022Article
- Bottlebrush polymers with flexible enantiomeric side chains display differential biological properties.Nature chemistry · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The combination of highly efficient polymerizations with modular "click" coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by "graft-through" ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click-to" coupling of a photocleavable doxorubicin (DOX)-alkyne derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6-∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically effective against human cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.