Evidence map›Paper›PMID 21140298›Full record

ReviewStem cell reviews and reports2011

The ins and outs of hematopoietic stem cells: studies to improve transplantation outcomes.

Leah A Marquez-Curtis, A Robert Turner, Santhi Sridharan, Mariusz Z Ratajczak, Anna Janowska-Wieczorek

Abstract readReview
In one paragraph

Review in Stem cell reviews and reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Trial
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  13. In vivo engineering of bone tissues with hematopoietic functions and mixed chimerism.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  14. Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal Degeneration.Molecular therapy : the journal of the American Society of Gene Therapy · 2017
    Article
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leah A Marquez-CurtisResearch & Development, Canadian Blood Services, CBS Edmonton Centre, 8249-114 St. NW, Edmonton, T6G 2R8, Alberta, Canada.
A Robert Turner
Santhi Sridharan
Mariusz Z Ratajczak
Anna Janowska-Wieczorek

Funding

Novel mechanisms involving complement cascade in stem cell traffickingR01DK074720 · NIDDK · UNIVERSITY OF LOUISVILLE · PI RATAJCZAK, MARIUSZ Z · 2007 to 2020
$4.1M
CIHR XE00025NCI NIH HHS R0I CA105847NIDDK NIH HHS R01 DK074720
6 · The paper itself

Abstract

Deciphering the mechanisms of hematopoietic stem/progenitor cell (HSPC) mobilization and homing is important for the development of strategies to enhance the efficacy of HSPC transplantation and achieve the full potential of HSPC-based cellular therapy. Investigation of these mechanisms has revealed interdependence among the various molecules, pathways and cellular components involved, and underscored the complex nature of these two processes. This review summarizes recent progress in identifying the specific factors implicated in HSPC mobilization and homing, with emphasis on our own work. Particularly, we will discuss our studies on stromal cell-derived factor-1 and its interaction with its receptor CXCR4, proteases (matrix metalloproteinases and carboxypeptidase M), complement proteins (C1q, C3a, C5a, membrane attack complex), sphingosine-1-phosphate, and pharmacologic agents such as the histone deacetylase inhibitor valproic acid and hyaluronic acid.

Indexed as

Hematopoietic Stem Cell TransplantationTreatment OutcomeAnimalsCell Adhesion MoleculesCell- and Tissue-Based TherapyComplement System ProteinsCytokinesHematopoietic Stem Cell MobilizationHematopoietic Stem CellsHumansImmunity, InnateIntercellular Signaling Peptides and ProteinsMatrix MetalloproteinasesStem Cell NicheCell Adhesion MoleculesComplement System ProteinsCytokinesIntercellular Signaling Peptides and ProteinsMatrix Metalloproteinases

Identifiers

PMID21140298
PMCPMC3113638

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.