ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2011
A three-dimensional cell biology model of human hepatocellular carcinoma in vitro.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- A Robust Marine Collagen Peptide-Agarose 3D Culture System for In Vitro Modeling of Hepatocellular Carcinoma and Anti-Cancer Therapeutic Development.Marine drugs · 2025Article
- Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction.International journal of molecular sciences · 2023Review
- Advancements and application prospects of three-dimensional models for primary liver cancer: a comprehensive review.Frontiers in bioengineering and biotechnology · 2023Review
- Three-dimensional (3D) cell culture: a valuable step in advancing treatments for human hepatocellular carcinoma.Cancer cell international · 2022Review
- The Fight against Cancer by Microgravity: The Multicellular Spheroid as a Metastasis Model.International journal of molecular sciences · 2022Review
- The Revolutionary Roads to Study Cell-Cell Interactions in 3D In Vitro Pancreatic Cancer Models.Cancers · 2021Review
- Establishment of rat liver cancer cell lines with different metastatic potential.Scientific reports · 2020Article
- Recreating Tumour Complexity in a Dish: Organoid Models to Study Liver Cancer Cells and their Extracellular Environment.Cancers · 2019Review
- Acute effect of lactic acid on tumor-endothelial cell metabolic coupling in the tumor microenvironment.Oncology letters · 2016Article
- Is There a Space-Based Technology Solution to Problems with Preclinical Drug Toxicity Testing?Pharmaceutical research · 2016Review
- Type conversion of secretomes in a 3D TAM2 and HCC cell co-culture system and functional importance of CXCL2 in HCC.Scientific reports · 2016Article
- Engineering cancer microenvironments forMaterials today (Kidlington, England) · 2015Article
- The study of energy metabolism in bladder cancer cells in co-culture conditions using a microfluidic chip.International journal of clinical and experimental medicine · 2015Article
- VEGFR-1 activation-induced MMP-9-dependent invasion in hepatocellular carcinoma.Future oncology (London, England) · 2015Article
- Dynamic expression patterns of differential proteins during early invasion of hepatocellular carcinoma.PloS one · 2014Article
- Screening candidate metastasis-associated genes in three-dimensional HCC spheroids with different metastasis potential.International journal of clinical and experimental pathology · 2014Article
- Vascular endothelial cells facilitated HCC invasion and metastasis through the Akt and NF-κB pathways induced by paracrine cytokines.Journal of experimental & clinical cancer research : CR · 2013Article
- Using space-based investigations to inform cancer research on Earth.Nature reviews. Cancer · 2013Review
- An engineered three-dimensional gastric tumor culture model for evaluating the antitumor activity of immune cells in vitro.Oncology letters · 2013Article
- An update to space biomedical research: tissue engineering in microgravity bioreactors.BioImpacts : BI · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We established an in vitro 3-D model of metastatic hepatocellular carcinoma (HCC) by culturing MHCC97H cells on molecular scaffolds within a rotating wall vessel bioreactor. Morphological and biochemical analyses revealed that the 3-D HCC model mirrored many clinical pathological features of HCC in vivo, including cancer cell morphology, tissue ultrastructure, protein production and secretion, glucose metabolism, tissue-specific gene expression, and apoptosis. Xenografts into livers of nude mice resulted in tumorigenesis and distant metastasis. This 3-D HCC spheroid is a promising model for HCC tumor biology, anticancer drug screening, and for the establishment of HCC animal models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.