ArticleCurrent microbiology2011
Efficacy of a broad host range lytic bacteriophage against E. coli adhered to urothelium.
Article in Current microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- UropathogenicAntibiotics (Basel, Switzerland) · 2026Review
- Isolation and characterization of a bacteriophage targeting Proteus mirabilis for use in culture media.BMC microbiology · 2026Article
- Isolation and Genomic Characterization of a Lytic Bacteriophage Against Multidrug-ResistantViruses · 2026Article
- UropathogenicMicroorganisms · 2023Review
- A metagenomic study of gut viral markers in amyloid-positive Alzheimer's disease patients.Alzheimer's research & therapy · 2023Article
- Interactions of Bacteriophages with Animal and Human Organisms-Safety Issues in the Light of Phage Therapy.International journal of molecular sciences · 2021Review
- Characterization of a Novel Bacteriophage swi2 Harboring Two Lysins Can Naturally LyseFrontiers in microbiology · 2021Article
- Phage Therapy as a Novel Strategy in the Treatment of Urinary Tract Infections Caused byAntibiotics (Basel, Switzerland) · 2020Review
- Managing urinary tract infections through phage therapy: a novel approach.Folia microbiologica · 2020Review
- Bacterial culture through selective and non-selective conditions: the evolution of culture media in clinical microbiology.New microbes and new infections · 2020Review
- Characterization of a Salmonella Enteritidis bacteriophage showing broad lytic activity against Gram-negative enteric bacteria.Journal of microbiology (Seoul, Korea) · 2018Article
- Characterization of theViruses · 2018Article
- Bacteriophage Isolated from Sewage Eliminates and Prevents the Establishment ofAdvanced pharmaceutical bulletin · 2018Article
- Applications for Bacteriophage Therapy during Pregnancy and the Perinatal Period.Frontiers in microbiology · 2017Review
- Phage therapy against Enterococcus faecalis in dental root canals.Journal of oral microbiology · 2016Review
- The rebirth of culture in microbiology through the example of culturomics to study human gut microbiota.Clinical microbiology reviews · 2015Article
- Tradeoffs in bacteriophage life histories.Bacteriophage · 2014Article
- Non contiguous-finished genome sequence and description of Enterobacter massiliensis sp. nov.Standards in genomic sciences · 2013Article
- Pseudomonas aeruginosa bacteriophage PA1Ø requires type IV pili for infection and shows broad bactericidal and biofilm removal activities.Applied and environmental microbiology · 2012Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent urinary tract infections (UTI) are often caused by E. coli adhered to urothelium. This type of cells is generally recognized as very tolerant to antibiotics which renders difficult the treatment of chronic UTI. This study investigates the use of lytic bacteriophages as alternative antimicrobial agents, particularly the interaction of phages with E. coli adhered to urothelium and specifically determines their efficiency against this type of cells. The bacterial adhesion to urothelium was performed varying the bacterial cell concentrations and the period and conditions (static, shaken) of adhesion. Three collection bacteriophages (T1, T4, and phiX174 like phages) were tested against clinical E. coli isolates and only one was selected for further infection experiments. Based on the lytic spectrum against clinical isolates and its ability to infect the highest number of antibiotic resistant strains, the T1-like bacteriophage was selected. This bacteriophage caused nearly a 45% reduction of the bacterial population after 2 h of treatment. This study provides evidence that bacteriophages are effective in controlling suspended and adhered cells and therefore can be a viable alternative to antibiotics to control urothelium- adhered bacteria.
Indexed as
Identifiers
21140149What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.