ArticleInternational journal of environmental research and public health2010
Chronic cigarette smoking: implications for neurocognition and brain neurobiology.
Article in International journal of environmental research and public health, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
122 citing papers in PubMed, 3 syntheses or guidelines pooled it, 244 citations in OpenAlex.
- Chronic tobacco smoking and neurocognitive impairments in adolescents and young adults: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations.Behavioral and brain functions : BBF · 2016Pooled it
- Smoking and increased Alzheimer's disease risk: a review of potential mechanisms.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014Pooled it
- Vitamin D, smoking, EBV, and long-term cognitive performance in MS: 11-year follow-up of BENEFIT.Neurology · 2020Trial
- Vaping Versus Smoking: Effects on Attention and Executive Functioning in Young Adults.Annals of neurosciences · 2026Article
- Time-based prospective memory impairment in adults who smoke: the role of internal and external attention and cue-based intervention.Psychopharmacology · 2026Article
- Screen-detected cognitive impairment, psychological distress, and quality of life in cancer patients undergoing chemotherapy in Yemen.BMC psychology · 2026Article
- The influence of vascular risk factors and aging on choroid plexus enlargement.European radiology · 2026Article
- Infratentorial cerebral microbleeds and brain age gap in stroke patients: a cross-sectional neuroimaging study.GeroScience · 2026Article
- The impact of e-cigarette use on cognitive function, emotional intelligence, and dementia risk in adolescents and young adults.Scientific reports · 2026Article
- Risk factors for developmental delays in small for gestational age children at age of 24-36 months.European child & adolescent psychiatry · 2026Article
- Protective Effect of Cordyceps militaris Extract Against Cigarette Smoke Extract Induced Neurodegeneration in Zebrafish Model.Neurotoxicity research · 2026Article
- Altered Brain Dynamics in Heavy Smokers Revealed by Dynamic Functional Network Connectivity Analysis.Brain topography · 2026Article
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Grey matter morphometry in young adult e-cigarette users, tobacco cigarette users & non-using controls.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Differences in Cerebral Small Vessel Disease Magnetic Resonance Imaging Depending on Cardiovascular Risk Factors: A Retrospective Cross-Sectional Study.Brain sciences · 2025Article
- A Genome-wide study on the genetic and causal effects of smoking in neurodegeneration.Journal of translational medicine · 2025Article
- The Hidden Threat of Microplastics in Traditional Cigarettes: A Narrative Review of Health and Environmental Risks.Journal of clinical medicine · 2025Review
- Association Between Smoking and Amnesia in Southwest Iran: A Population-Based Cross-sectional Study.Journal of research in health sciences · 2025Article
- Understanding causal estimates of smoking behaviors for cognitive impairment: A Mendelian randomization study.Journal of Alzheimer's disease : JAD · 2025Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Compared to the substantial volume of research on the general health consequences associated with chronic smoking, little research has been specifically devoted to the investigation of its effects on human neurobiology and neurocognition. This review summarizes the peer-reviewed literature on the neurocognitive and neurobiological implications of chronic cigarette smoking in cohorts that were not seeking treatment for substance use or psychiatric disorders. Studies that specifically assessed the neurocognitive or neurobiological (with emphasis on computed tomography and magnetic resonance-based neuroimaging studies) consequences of chronic smoking are highlighted. Chronic cigarette smoking appears to be associated with deficiencies in executive functions, cognitive flexibility, general intellectual abilities, learning and/or memory processing speed, and working memory. Chronic smoking is related to global brain atrophy and to structural and biochemical abnormalities in anterior frontal regions, subcortical nuclei and commissural white matter. Chronic smoking may also be associated with an increased risk for various forms of neurodegenerative diseases. The existing literature is limited by inconsistent accounting for potentially confounding biomedical and psychiatric conditions, focus on cross-sectional studies with middle aged and older adults and the absence of studies concurrently assessing neurocognitive, neurobiological and genetic factors in the same cohort. Consequently, the mechanisms promoting the neurocognitive and neurobiological abnormalities reported in chronic smokers are unclear. Longitudinal studies are needed to determine if the smoking-related neurobiological and neurocognitive abnormalities increase over time and/or show recovery with sustained smoking cessation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.