ArticleMolecular vision2010
Molecular epidemiology of adenoviral keratoconjunctivitis in Saudi Arabia.
Article in Molecular vision, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Efficacy and Safety of Ophthalmic Preparations of Glucocorticoids in Patients with Epidemic Keratoconjunctivitis: A Systematic Review and Meta-analysis.Therapeutic innovation & regulatory science · 2023Pooled it
- Topical pharmacologic interventions versus placebo for epidemic keratoconjunctivitis.The Cochrane database of systematic reviews · 2022Pooled it
- Molecular and Clinical Characterization of Human Adenovirus E4-Associated Conjunctivitis.American journal of ophthalmology · 2022Trial
- Determinants of Outcomes of Adenoviral Keratoconjunctivitis.Ophthalmology · 2018Trial
- Genotyping and Clinical Manifestations of Adenoviral Keratoconjunctivitis in South Korea.Korean journal of ophthalmology : KJO · 2026Article
- Epidemiologic and clinical updates on viral infections in Saudi Arabia.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- In Silico Intensive Analysis for the E4 Gene Evolution of Human Adenovirus Species D.Journal of microbiology (Seoul, Korea) · 2024Article
- Multi-parametric evaluation of ocular surface disorders during healing process of viral conjunctivitis.International ophthalmology · 2022Article
- Prevalence of adenoviruses as ocular disease causatives in Saudi Arabia.Saudi journal of biological sciences · 2022Review
- Review
- An outbreak of epidemic keratoconjunctivitis caused by human adenovirus type 8 in primary school, southwest China.BMC infectious diseases · 2019Article
- Frequency of adenovirus serotype 8 in patients with Keratoconjunctivitis, in Ahvaz, Iran.Iranian journal of microbiology · 2019Article
- Epidemiology and molecular diagnosis of acute conjunctivitis in patients attending Hamadan, west Iran ophthalmology clinics 2016-2017.Clinical optometry · 2019Article
- Adenovirus-associated acute conjunctivitis in Beijing, China, 2011-2013.BMC infectious diseases · 2018Article
- Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention.Seminars in respiratory and critical care medicine · 2016Review
- Human adenovirus type 8 epidemic keratoconjunctivitis with large corneal epithelial full-layer detachment: an endemic outbreak with uncommon manifestations.Clinical ophthalmology (Auckland, N.Z.) · 2015Article
- Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters.Antimicrobial agents and chemotherapy · 2014Article
- Role of molecular diagnostics in ocular microbiology.Current ophthalmology reports · 2013Article
- Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis during 1986-2003 in Japan.Molecular vision · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdenoviral keratoconjunctivitis is a major cause of ocular morbidity and may lead to visual loss. Adenovirus types 8, 19, and 37 may cause epidemic keratoconjunctivitis. The main objective of this study was to determine the types of adenoviruses causing keratoconjunctivitis in Saudi Arabia.
methodsWe conducted a non-interventional observational clinical study. Seventy three eyes from 65 patients who presented to The Eye Center in Riyadh, Saudi Arabia with clinical features of acute adenoviral keratoconjunctivitis were included. Each patient underwent complete clinical examination and features such as membranous reaction, conjunctival hemorrhage, subepithelial corneal infiltrates, and preauricular lymph node enlargement were recorded. Conjunctival swabs were obtained from patients with presumed acute viral conjunctivitis. Immunochromatography (IC) and restriction fragment length polymorphism polymerase chain reaction (PCR-RFLP) were performed on the conjunctival swabs obtained from each eye. Serotype identification was performed using direct sequencing technique.
resultsForty-nine (67.1%) were adenovirus type 8, 8 (11.0%) were adenovirus type 3, 6 (8.2%) type 37, 5 (6.8%) were adenovirus type 4, and 2 (2.3%) type 19. The remaining 5 were types 14, 19, and 22. The prevalence of membranous conjunctivitis was highest (83%) among eyes with adenovirus type 37 while subepithelial corneal opacities were most commonly seen among eyes with adenovirus type 8 (47%). Immunochromatography tests were positive for adenovirus in 48 (65.7%) out of 73 eyes.
conclusionsThis study determined the types of adenoviruses causing keratoconjunctivitis at one center in Saudi Arabia. Direct sequencing techniques is an efficient, accurate, and rapid means of diagnosing adenoviral keratoconjunctivitis. The most common causes of adenoviral keratoconjunctivitis in Saudi Arabia were adenovirus types 8, 3, and 37. Membranous conjunctivitis and subepithelial opacities had the highest frequency of adenovirus types 37 and 8, respectively. Lymph nodes enlargement was least likely in adenovirus type 4.
Indexed as
Identifiers
21139691PMC2994420W1745848242What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.