Evidence map›Paper›PMID 21139420›Full record

ReviewChannels (Austin, Tex.)

Contributions of T-type calcium channel isoforms to neuronal firing.

Stuart M Cain, Terrance P Snutch

Open access · goldAbstract readReview
In one paragraph

Review in Channels (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 215 citations in OpenAlex.

  1. Review
  2. Article
  3. Bioelectric state transitions enablebioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  6. Article
  7. Tension shapes memory: computational insights into neural plasticity.Frontiers in computational neuroscience · 2026
    Article
  8. Article
  9. Article
  10. Intrinsic Dendritic Integration Features of Prefrontal Layer 5 Pyramidal Cell Subclasses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. CaScientific reports · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Stuart M CainMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada. snutch@msl.ubc.ca
Terrance P Snutch
Canada's Michael Smith Genome Sciences Centre · CAUniversity of British Columbia · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

Low voltage-activated (LVA) T-type calcium channels play critical roles in the excitability of many cell types and are a focus of research aimed both at understanding the physiological basis of calcium channel-dependent signaling and the underlying pathophysiology associated with hyperexcitability disorders such as epilepsy.  These channels play a critical role towards neuronal firing in both conducting calcium ions during action potentials and also in switching neurons between distinct modes of firing.  In this review the properties of the CaV3.1, CaV3.2 and CaV3.3 T-type channel isoforms is discussed in relation to their individual contributions to action potentials during burst and tonic firing states as well their roles in switching between firing states.

Indexed as

Calcium SignalingAction PotentialsAnimalsCalciumCalcium Channels, T-TypeHumansKineticsNeuronsProtein IsoformsCalciumCalcium Channels, T-TypeProtein Isoforms

Identifiers

PMID21139420
PMCPMC3052247
OpenAlexW2138970396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.