Trial reportJAMA2010
Integrating tobacco cessation into mental health care for posttraumatic stress disorder: a randomized controlled trial.
Trial report in JAMA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00118534 (CSP #519 - Integrating Practice Guidelines for Smoking Cessation Into Mental Health Care for PTSD), which is not on this map. Cited by 117 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CSP #519 - Integrating Practice Guidelines for Smoking Cessation Into Mental Health Care for PTSD (SCP)
Who cites it
117 citing papers in PubMed, 8 syntheses or guidelines pooled it, 213 citations in OpenAlex.
- Implementation strategies to increase tobacco treatment in mental health settings: a systematic review.BMC psychiatry · 2025Pooled it
- Posttraumatic stress disorder and tobacco use: A systematic review and meta-analysis.Addictive behaviors · 2018Pooled it
- Action and inaction in multi-behaviour recommendations: a meta-analysis of lifestyle interventions.Health psychology review · 2018Pooled it
- System change interventions for smoking cessation.The Cochrane database of systematic reviews · 2017Pooled it
- Pooled it
- Smoking cessation interventions for adults aged 50 or older: A systematic review and meta-analysis.Drug and alcohol dependence · 2015Pooled it
- Smoking cessation interventions for smokers with current or past depression.The Cochrane database of systematic reviews · 2013Pooled it
- Tobacco and marijuana use among adolescents and young adults: a systematic review of their co-use.Clinical psychology review · 2012Pooled it
- Cessation of smoking in people attending UK emergency departments: the COSTED RCT with economic and process evaluation.Health technology assessment (Winchester, England) · 2025Trial
- Smoking Cessation Interventions in the Lung Cancer Screening Setting: A Randomized Clinical Trial.JAMA internal medicine · 2025Trial
- Cessation of Smoking Trial in the Emergency Department (COSTED): a multicentre randomised controlled trial.Emergency medicine journal : EMJ · 2024Trial
- The effectiveness of a telephone smoking cessation program in mental health clinic patients by level of mental well-being and functioning: a secondary data analysis of a randomized clinical trial.BMC public health · 2023Trial
- Psychiatric Comorbidity and Multimorbidity in the EAGLES Trial: Descriptive Correlates and Associations With Neuropsychiatric Adverse Events, Treatment Adherence, and Smoking Cessation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021Trial
- Longitudinal Association Between Smoking Abstinence and Depression Severity in Those With Baseline Current, Past, and No History of Major Depressive Episode in an International Online Tobacco Cessation Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021Trial
- Proactive tobacco treatment for veterans with posttraumatic stress disorder.Psychological trauma : theory, research, practice and policy · 2021Trial
- Efficacy and safety of pharmacotherapies for smoking cessation in anxiety disorders: Subgroup analysis of the randomized, active- and placebo-controlled EAGLES trial.Depression and anxiety · 2020Trial
- Concurrent varenicline and prolonged exposure for patients with nicotine dependence and PTSD: A randomized controlled trial.Journal of consulting and clinical psychology · 2017Trial
- Abstinence Reinforcement Therapy (ART) for rural veterans: Methodology for an mHealth smoking cessation intervention.Contemporary clinical trials · 2016Trial
- Cost-Effectiveness of Integrating Tobacco Cessation Into Post-Traumatic Stress Disorder Treatment.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Trial
- Multicomponent smoking cessation treatment including mobile contingency management in homeless veterans.The Journal of clinical psychiatry · 2015Trial
57 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
16 authors at 1 institution in 1 country.
Funding
Abstract
contextMost smokers with mental illness do not receive tobacco cessation treatment.
objectiveTo determine whether integrating smoking cessation treatment into mental health care for veterans with posttraumatic stress disorder (PTSD) improves long-term smoking abstinence rates. DESIGN, SETTING, AND PATIENTS: A randomized controlled trial of 943 smokers with military-related PTSD who were recruited from outpatient PTSD clinics at 10 Veterans Affairs medical centers and followed up for 18 to 48 months between November 2004 and July 2009.
interventionSmoking cessation treatment integrated within mental health care for PTSD delivered by mental health clinicians (integrated care [IC]) vs referral to Veterans Affairs smoking cessation clinics (SCC). Patients received smoking cessation treatment within 3 months of study enrollment.
main outcome measuresSmoking outcomes included 12-month bioverified prolonged abstinence (primary outcome) and 7- and 30-day point prevalence abstinence assessed at 3-month intervals. Amount of smoking cessation medications and counseling sessions delivered were tested as mediators of outcome. Posttraumatic stress disorder and depression were repeatedly assessed using the PTSD Checklist and Patient Health Questionnaire 9, respectively, to determine if IC participation or quitting smoking worsened psychiatric status.
resultsIntegrated care was better than SCC on prolonged abstinence (8.9% vs 4.5%; adjusted odds ratio, 2.26; 95% confidence interval [CI], 1.30-3.91; P = .004). Differences between IC vs SCC were largest at 6 months for 7-day point prevalence abstinence (78/472 [16.5%] vs 34/471 [7.2%], P < .001) and remained significant at 18 months (86/472 [18.2%] vs 51/471 [10.8%], P < .001). Number of counseling sessions received and days of cessation medication used explained 39.1% of the treatment effect. Between baseline and 18 months, psychiatric status did not differ between treatment conditions. Posttraumatic stress disorder symptoms for quitters and nonquitters improved. Nonquitters worsened slightly on the Patient Health Questionnaire 9 relative to quitters (differences ranged between 0.4 and 2.1, P = .03), whose scores did not change over time.
conclusionAmong smokers with military-related PTSD, integrating smoking cessation treatment into mental health care compared with referral to specialized cessation treatment resulted in greater prolonged abstinence.
trial registrationclinicaltrials.gov Identifier: NCT00118534.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.