ArticleThe Plant cell2010
The Arabidopsis cell cycle F-box protein SKP2A binds to auxin.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 158 citations in OpenAlex.
- Multi-Season Genome-Wide Association Study Reveals Loci and Candidate Genes for Fruit Quality and Maturity Traits in Peach.Plants (Basel, Switzerland) · 2026Article
- Auxin Biosynthesis, Transport, Signaling, and Its Roles in Plant Leaf Morphogenesis.Plants (Basel, Switzerland) · 2025Review
- Hormonal regulation of root growth under moderately elevated temperatures.Annals of botany · 2025Review
- Article
- Shaping root architecture: towards understanding the mechanisms involved in lateral root development.Biology direct · 2024Review
- Advances in Plant Auxin Biology: Synthesis, Metabolism, Signaling, Interaction with Other Hormones, and Roles under Abiotic Stress.Plants (Basel, Switzerland) · 2024Review
- Protein degradation in auxin response.The Plant cell · 2024Review
- WAV E3 ubiquitin ligases mediate degradation of IAA32/34 in the TMK1-mediated auxin signaling pathway during apical hook development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- A systems genetic analysis identifies putative mechanisms and candidate genes regulating vessel traits in poplar wood.Frontiers in plant science · 2024Article
- What a tangled web it weaves: auxin coordination of stem cell maintenance and flower production.Journal of experimental botany · 2023Article
- Transcriptional Profiling Reveals the Wheat Defences against Fusarium Head Blight Disease Regulated by a NAC Transcription Factor.Plants (Basel, Switzerland) · 2023Article
- Canonical and Alternative Auxin Signaling Systems in Mono-, Di-, and Tetraploid Potatoes.International journal of molecular sciences · 2023Article
- Auxin signaling is essential for organogenesis but not for cell survival in the liverwort Marchantia polymorpha.The Plant cell · 2023Article
- Different Tactics of Synthesized Zinc Oxide Nanoparticles, Homeostasis Ions, and Phytohormones as Regulators and Adaptatively Parameters to Alleviate the Adverse Effects of Salinity Stress on Plants.Life (Basel, Switzerland) · 2022Review
- Molecular Mechanisms of Diverse Auxin Responses during Plant Growth and Development.International journal of molecular sciences · 2022Review
- Physiological and Transcriptomic Analyses Reveal the Mechanisms of Compensatory Growth Ability for Early Rice after Low Temperature and Weak Light Stress.Plants (Basel, Switzerland) · 2022Article
- Emerging roles of the ubiquitin-proteasome pathway in enhancing crop yield by optimizing seed agronomic traits.Plant cell reports · 2022Review
- A common F-box gene regulates the leucine homeostasis of Medicago truncatula and Arabidopsis thaliana.Protoplasma · 2022Article
- Synthesis and regulation of auxin and abscisic acid in maize.Plant signaling & behavior · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arabidopsis thaliana S-Phase Kinase-Associated Protein 2A (SKP2A) is an F-box protein that regulates the proteolysis of cell cycle transcription factors. The plant hormone auxin regulates multiple aspects of plant growth and development, including cell division. We found that auxin induces the ubiquitin-dependent degradation of SKP2A both in vivo and in vitro, suggesting that this hormone acts as a signal to trigger SKP2A proteolysis. In this article, we show that auxin binds directly and specifically to SKP2A. By TIR1-based superposition and docking analyzes, we identified an auxin binding site in SKP2A. Mutations in this binding site reduce the ability of SKP2A to bind to auxin and generate nondegradable SKP2A forms. In addition, these non-auxin binding proteins are unable to promote E2FC/DPB degradation in vivo or to induce cell division in the root meristem. Auxin binds to TIR1 to promote its interaction with the auxin/indole-3-acetic acid target proteins. Here, we show that auxin also enhanced the interaction between SKP2A and DPB. Finally, a mutation in SKP2A leads to auxin-resistant root growth, an effect that is additive with the tir1-1 phenotype. Thus, our data indicate that SKP2A is an auxin binding protein that connects auxin signaling with cell division.
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