ArticleNucleic acids research2011
Molecular anatomy of the Streptococcus pyogenes pSM19035 partition and segrosome complexes.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 33 citations in OpenAlex.
- Insights into the molecular mechanism of ParABS system in chromosome partition by HpParA and HpParB.Nucleic acids research · 2024Article
- Distinct architectural requirements for theeLife · 2022Article
- Catching a Walker in the Act-DNA Partitioning by ParA Family of Proteins.Frontiers in microbiology · 2022Review
- Chromosome segregation in Archaea: SegA- and SegB-DNA complex structures provide insights into segrosome assembly.Nucleic acids research · 2021Article
- Molecular and Structural Parallels between Gluten Pathogenic Peptides and Bacterial-Derived Proteins by Bioinformatics Analysis.International journal of molecular sciences · 2021Article
- Nonspecific DNA binding by P1 ParA determines the distribution of plasmid partition and repressor activities.The Journal of biological chemistry · 2020Article
- Crystal structures of HpSoj-DNA complexes and the nucleoid-adaptor complex formation in chromosome segregation.Nucleic acids research · 2019Article
- Molecular characterization of an unauthorized genetically modified Bacillus subtilis production strain identified in a vitamin BFood chemistry · 2017Article
- A three-dimensional ParF meshwork assembles through the nucleoid to mediate plasmid segregation.Nucleic acids research · 2017Article
- Antibiotic Resistance-Susceptibility Profiles ofFrontiers in microbiology · 2017Article
- The interaction of ω2 with the RNA polymerase β' subunit functions as an activation to repression switch.Nucleic acids research · 2015Article
- Molecular Anatomy of ParA-ParA and ParA-ParB Interactions during Plasmid Partitioning.The Journal of biological chemistry · 2015Article
- ParAB Partition Dynamics in Firmicutes: Nucleoid Bound ParA Captures and Tethers ParB-Plasmid Complexes.PloS one · 2015Article
- Specific and non-specific interactions of ParB with DNA: implications for chromosome segregation.Nucleic acids research · 2015Article
- Article
- ParA-mediated plasmid partition driven by protein pattern self-organization.The EMBO journal · 2013Article
- Plasmid partition: sisters drifting apart.The EMBO journal · 2013Article
- Cell-free study of F plasmid partition provides evidence for cargo transport by a diffusion-ratchet mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Surfing biological surfaces: exploiting the nucleoid for partition and transport in bacteria.Molecular microbiology · 2012Review
- Functional characterization of the role of the chromosome I partitioning system in genome segregation in Deinococcus radiodurans.Journal of bacteriology · 2012Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vancomycin or erythromycin resistance and the stability determinants, δω and ωεζ, of Enterococci and Streptococci plasmids are genetically linked. To unravel the mechanisms that promoted the stable persistence of resistance determinants, the early stages of Streptococcus pyogenes pSM19035 partitioning were biochemically dissected. First, the homodimeric centromere-binding protein, ω2, bound parS DNA to form a short-lived partition complex 1 (PC1). The interaction of PC1 with homodimeric δ [δ2 even in the apo form (Apo-δ2)], significantly stimulated the formation of a long-lived ω2·parS complex (PC2) without spreading into neighbouring DNA sequences. In the ATP·Mg2+ bound form, δ2 bound DNA, without sequence specificity, to form a transient dynamic complex (DC). Second, parS bound ω2 interacted with and promoted δ2 redistribution to co-localize with the PC2, leading to transient segrosome complex (SC, parS·ω2·δ2) formation. Third, δ2, in the SC, interacted with a second SC and promoted formation of a bridging complex (BC). Finally, increasing ω2 concentrations stimulated the ATPase activity of δ2 and the BC was disassembled. We propose that PC, DC, SC and BC formation were dynamic processes and that the molar ω2:δ2 ratio and parS DNA control their temporal and spatial assembly during partition of pSM19035 before cell division.
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