ArticleHuman molecular genetics2011
Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla.
Article in Human molecular genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Tails of nephron ciliated cell development: insights on patterning a functional tissue barrier from the zebrafish.Tissue barriers · 2024Review
- Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney.The American journal of pathology · 2023Article
- Esrrγa regulates nephron and ciliary development by controlling prostaglandin synthesis.Development (Cambridge, England) · 2023Article
- Rac1 deficiency impairs postnatal development of the renal papilla.Scientific reports · 2022Article
- Bioinformatic gene analysis for possible biomarkers and therapeutic targets of hypertension-related renal cell carcinoma.Translational andrology and urology · 2020Article
- Cellular Recruitment by Podocyte-Derived Pro-migratory Factors in Assembly of the Human Renal Filter.iScience · 2019Article
- Genomic integration of ERRγ-HNF1β regulates renal bioenergetics and prevents chronic kidney disease.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice.American journal of human genetics · 2017Article
- A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans.Genetics · 2017Article
- CONSERVED AND EXAPTED FUNCTIONS OF NUCLEAR RECEPTORS IN ANIMAL DEVELOPMENT.Nuclear receptor research · 2017Article
- The multi-omic landscape of transcription factor inactivation in cancer.Genome medicine · 2016Article
- Positional plasticity in regenerating Amybstoma mexicanum limbs is associated with cell proliferation and pathways of cellular differentiation.BMC developmental biology · 2015Article
- Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function.Molecular and cellular biology · 2015Article
- The ureteric bud epithelium: morphogenesis and roles in metanephric kidney patterning.Molecular reproduction and development · 2015Review
- Transcriptional consequences of 16p11.2 deletion and duplication in mouse cortex and multiplex autism families.American journal of human genetics · 2014Article
- Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source.Nature cell biology · 2014Article
- Article
- Angiotensin II regulates growth of the developing papillas ex vivo.American journal of physiology. Renal physiology · 2012Article
- Role of microRNAs in controlling gene expression in different segments of the human epididymis.PloS one · 2012Article
- Wnt signaling and renal medulla formation.Pediatric nephrology (Berlin, Germany) · 2011Review
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
Congenital anomalies of the kidney and urinary tract (CAKUTs) are common disorders of human development affecting the renal parechyma, renal pelvis, ureter, bladder and urethra; they show evidence of shared genetic aetiology, although the molecular basis of this remains unknown in the majority of cases. Breakpoint mapping of a de novo, apparently balanced, reciprocal translocation associated with bilateral renal agenesis has implicated the gene encoding the nuclear steroid hormone receptor ESRRG as a candidate gene for CAKUT. Here we show that the Esrrg protein is detected throughout early ureteric ducts as cytoplasmic/sub-membranous staining; with nuclear localization seen in developing nephrons. In 14.5-16.5 dpc (days post-conception) mouse embryos, Esrrg localizes to the subset of ductal tissue within the kidney, liver and lung. The renal ductal expression becomes localized to renal papilla by 18.5 dpc. Perturbation of function was performed in embryonic mouse kidney culture using pooled siRNA to induce knock-down and a specific small-molecule agonist to induce aberrant activation of Esrrg. Both resulted in severe abnormality of early branching events of the ureteric duct. Mouse embryos with a targeted inactivation of Esrrg on both alleles (Esrrg(-/-)) showed agenesis of the renal papilla but normal development of the cortex and remaining medulla. Taken together, these results suggest that Esrrg is required for early branching events of the ureteric duct that occur prior to the onset of nephrogenesis. These findings confirm ESRRG as a strong candidate gene for CAKUT.
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