ReviewEuropean heart journal2011
Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment.
Review in European heart journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 460 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Retrospective Observational Analysis of a Cohort With Heart Failure With Preserved Ejection Fraction From a BNP Pathway Clinic
Heart Failure and Preserved Ejection Fraction: Observation of Its Progression and Prognosis (HOPP-BERN)
Who cites it
460 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Comparison of vasodilators for heart failure: a systematic review and network meta-analysis of RCTs.BMC cardiovascular disorders · 2026Pooled it
- Association of COPD with adverse outcomes in heart failure patients with preserved ejection fraction.ESC heart failure · 2025Pooled it
- Pooled it
- Sodium-glucose co-transporter 2 inhibitors in heart failure with mildly reduced or preserved ejection fraction: an updated systematic review and meta-analysis.European journal of medical research · 2022Pooled it
- Effect of pharmacological treatment on outcomes of heart failure with preserved ejection fraction: an updated systematic review and network meta-analysis of randomized controlled trials.Cardiovascular diabetology · 2022Pooled it
- Diagnostic value of echocardiographic markers for diastolic dysfunction and heart failure with preserved ejection fraction.Heart failure reviews · 2022Pooled it
- The utility of growth differentiation factor-15, galectin-3, and sST2 as biomarkers for the diagnosis of heart failure with preserved ejection fraction and compared to heart failure with reduced ejection fraction: a systematic review.Heart failure reviews · 2021Pooled it
- Efficacy of azilsartan on left ventricular diastolic dysfunction compared with candesartan: J-TASTE randomized controlled trial.Scientific reports · 2023Trial
- Discriminative Role of Invasive Left Heart Catheterization in Patients Suspected of Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2023Trial
- Left Atrial Stiffness Index Independently Predicts Exercise Intolerance and Quality of Life in Older, Obese Patients With Heart Failure With Preserved Ejection Fraction.Journal of cardiac failure · 2022Trial
- The effect of spironolactone on diastolic function in haemodialysis patients.The international journal of cardiovascular imaging · 2021Trial
- Associations of Left Ventricular Structure and Function With Blood Pressure in Heart Failure With Preserved Ejection Fraction: Analysis of the TOPCAT Trial.Journal of the American Heart Association · 2020Trial
- Myocardial Effects of Aldosterone Antagonism in Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2020Trial
- Potential roles for transient receptor potential vanilloid 1 in heart failure with preserved ejection fraction.Channels (Austin, Tex.) · 2026Review
- Diastolic contributors in cardiomyocytes of a cardiometabolic HFpEF-like mouse model.The Journal of general physiology · 2026Article
- Slow calcium removal contributes to impaired lusitropic response to β-adrenergic stimulation in HFpEF mice.The Journal of physiology · 2026Article
- Integration of multiple perspectives to understand the left ventricular pressure-volume relationship.Communications medicine · 2026Review
- Heart failure with preserved ejection fraction in women: a sex-specific clinical review.The Korean journal of internal medicine · 2026Review
- Diagnostic Performance of Guideline-Recommended B-Type Natriuretic Peptide Thresholds for Detecting Elevated Left Ventricular End-Diastolic Pressure.Diagnostics (Basel, Switzerland) · 2026Article
- Rethinking Symptom Fluctuation in Multimorbidity: A Dynamic Systems Framework From Primary Care.Journal of evaluation in clinical practice · 2026Article
400 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Half of patients with heart failure (HF) have a preserved left ventricular ejection fraction (HFpEF). Morbidity and mortality in HFpEF are similar to values observed in patients with HF and reduced EF, yet no effective treatment has been identified. While early research focused on the importance of diastolic dysfunction in the pathophysiology of HFpEF, recent studies have revealed that multiple non-diastolic abnormalities in cardiovascular function also contribute. Diagnosis of HFpEF is frequently challenging and relies upon careful clinical evaluation, echo-Doppler cardiography, and invasive haemodynamic assessment. In this review, the principal mechanisms, diagnostic approaches, and clinical trials are reviewed, along with a discussion of novel treatment strategies that are currently under investigation or hold promise for the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.