ArticleArchives of disease in childhood. Fetal and neonatal edition2011
Early postnatal hypotension and developmental delay at 24 months of age among extremely low gestational age newborns.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03086473 (A Randomized, Placebo-controlled Trial of Early Caffeine in Preterm Neonates), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Placebo-controlled Trial of Early Caffeine in Preterm Neonates
Who cites it
22 citing papers in PubMed.
- Outcomes of extremely preterm infants who participated in a randomised trial of dopamine for treatment of hypotension (the HIP trial) at 2 years corrected age.Archives of disease in childhood. Fetal and neonatal edition · 2025Trial
- Use of antihypotensive therapies in extremely preterm infants.Pediatrics · 2013Trial
- Feasibility study of early blood pressure management in extremely preterm infants.The Journal of pediatrics · 2012Trial
- Cardiorespiratory interactions during the transitional period in extremely preterm infants: a narrative review.Pediatric research · 2025Review
- An Update on Pharmacologic Management of Neonatal Hypotension: When, Why, and Which Medication.Children (Basel, Switzerland) · 2024Review
- [Risk factors and prognosis of hypotension within 72 hours after birth in extremely preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- Strong Association between Inotrope Administration and Intraventricular Hemorrhage, Gestational Age, and the Use of Fentanyl in Very Low Gestational Age Infants: A Retrospective Study.Children (Basel, Switzerland) · 2023Article
- Blood pressure values and hypotension management in extremely preterm infants: a multi-center study.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Vasoactive medications in extremely low gestational age neonates during the first postnatal week.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Risk Factors of Mechanical Ventilation in Premature Infants During Hospitalization.Therapeutics and clinical risk management · 2021Article
- Complications associated with the current sequential pharmacological management of early postnatal hypotension in extremely premature infants.Proceedings (Baylor University. Medical Center) · 2019Article
- Validity of Biomarkers of Early Circulatory Impairment to Predict Outcome: A Retrospective Analysis.Frontiers in pediatrics · 2019Article
- Antenatal and Neonatal Antecedents of Executive Dysfunctions in Extremely Preterm Children.Journal of child neurology · 2018Observational
- Antenatal and neonatal antecedents of learning limitations in 10-year old children born extremely preterm.Early human development · 2018Article
- Newborn blood gas derangements of children born extremely preterm and neurocognitive dysfunctions at age 10 years.Respiratory physiology & neurobiology · 2017Observational
- Early postnatal illness severity scores predict neurodevelopmental impairments at 10 years of age in children born extremely preterm.Journal of perinatology : official journal of the California Perinatal Association · 2017Observational
- Inotropes do not increase cardiac output or cerebral blood flow in preterm piglets.Pediatric research · 2016Article
- Early blood pressure, antihypotensive therapy and outcomes at 18-22 months' corrected age in extremely preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2016Observational
- Challenges in Treating Low Blood Pressure in Preterm Infants.Children (Basel, Switzerland) · 2015Review
- International survey on diagnosis and management of hypotension in extremely preterm babies.European journal of pediatrics · 2014Article
Corrections and comments
- Commented on by
Authors and funding
10 authors.
Funding
Abstract
objectivesTo evaluate in extremely low gestational age newborns, relationships between indicators of hypotension during the first 24 postnatal hours and developmental delay at 24 months of age.
methodsThe 945 infants in this prospective study were born at <28 weeks, were assessed for three indicators of hypotension in the first 24 postnatal hours, and were evaluated with the Bayley Mental Development Index (MDI) and Psychomotor Development Index (PDI) at 24 months corrected age. Indicators of hypotension included: (1) mean arterial pressure in the lowest quartile for gestational age; (2) treatment with a vasopressor; and (3) blood pressure lability, defined as the upper quartile for the difference between the lowest and highest mean arterial pressure. Logistic regression was used to evaluate relationships between hypotension and developmental outcomes, adjusting for potential confounders.
results78% of infants in this cohort received volume expansion or vasopressor; all who received a vasopressor were treated with volume expansion. 26% had an MDI <70 and 32% had a PDI <70. Low MDI and PDI were associated with low gestational age, which in turn, was associated with receipt of vasopressor treatment. Blood pressure in the lowest quartile for gestational age was associated with vasopressor treatment and labile blood pressure. After adjusting for potential confounders, none of the indicators of hypotension were associated with MDI <70 or PDI <70.
conclusionsIn this large cohort of extremely low gestational age newborns, we found little evidence that early postnatal hypotension indicators are associated with developmental delay at 24 months corrected gestational age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.