ArticleJournal of psychiatry & neuroscience : JPN2011
Depression in patients with Huntington disease correlates with alterations of the brain stem raphe depicted by transcranial sonography.
Article in Journal of psychiatry & neuroscience : JPN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- The pathobiology of depression in Huntington's disease: an unresolved puzzle.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- The relationship between disease-specific psychosocial stressors and depressive symptoms in Huntington's disease.Journal of neurology · 2024Article
- Echogenicity of Brain Structures in Huntington's Disease Patients Evaluated by Transcranial Sonography - Magnetic Resonance Fusion Imaging using Virtual Navigator and Digital Image Analysis.Ultraschall in der Medizin (Stuttgart, Germany : 1980) · 2023Article
- Prognostic markers of post-stroke depression (PROMoSD): study protocol of a prospective single-center observational study on raphe hypoechogenicity as a predictor of post-stroke depression.Neurological research and practice · 2022Article
- Hypoechogenicity of brainstem raphe in long-COVID syndrome-less common but independently associated with depressive symptoms: a cross-sectional study.Journal of neurology · 2022Article
- Different depression: motivational anhedonia governs antidepressant efficacy in Huntington's disease.Brain communications · 2022Article
- Neurosonological Findings Related to Non-Motor Features of Parkinson's Disease: A Systematic Review.Brain sciences · 2021Review
- Significant Association Between Huntingtin Gene Mutation and Prevalence of Hopelessness, Depression and Anxiety Symptoms.Acta medica Lituanic · 2021Review
- Alterations in transcranial sonography among Huntington's disease patients with psychiatric symptoms.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Hypoechogenicity of brainstem raphe correlates with depression in migraine patients.The journal of headache and pain · 2019Article
- An image-based model of brain volume biomarker changes in Huntington's disease.Annals of clinical and translational neurology · 2018Article
- Raphe nuclei echogenicity changes in obsessive-compulsive disorder.Medical journal of the Islamic Republic of Iran · 2018Article
- Brainstem Raphe Alterations in TCS: A Biomarker for Depression and Apathy in Parkinson's Disease Patients.Frontiers in neurology · 2018Article
- The Depressed Frail Phenotype: The Clinical Manifestation of Increased Biological Aging.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2016Review
- Alteration of brainstem raphe measured by transcranial sonography in depression patients with or without Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- Echogenicity of basal ganglia structures in different Huntington's disease phenotypes.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Viral vector mediated expression of mutant huntingtin in the dorsal raphe produces disease-related neuropathology but not depressive-like behaviors in wildtype mice.Brain research · 2015Article
- Substantia nigra hyperechogenicity in hypokinetic Huntington's disease patients.Journal of neurology · 2015Article
- Transcranial midbrain sonography and depressive symptoms in patients with Parkinson's disease.Journal of neurology · 2015Article
- Evaluation of CNS involvement in myotonic dystrophy type 1 and type 2 by transcranial sonography.Journal of neurology · 2015Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscranial sonography (TCS) has become a new diagnostic tool in the evaluation of extrapyramidal disorders. Studies of TCS report alterations of the mesencephalic raphe in patients with depression. The aim of this study was to evaluate TCS findings in patients with Huntington disease in correlation with their neurologic and psychiatric status.
methodsWe recruited patients with genetically confirmed Huntington disease. The neurological and psychiatric status of participants was assessed by independent physicians. Echogenicities were investigated according to examination protocol for extrapyramidal disorders using a Siemens Sonoline Elegra system. The sonography examiner was blinded for clinical data.
resultsWe included 39 patients in our study; 21 patients (53.8%) showed symptoms of depression at the time of evaluation and, of those, 15 (71.4%) had hypoechogenic raphe structures. Thirty patients (76.9%) had a history of depressive episodes, 19 (63.3%) of them with hypoechogenic raphe structures. All 9 patients without a history of depressive episodes showed normal echogenicity of raphe structures (sensitivity 63.3%, specificity 100%). Twelve (70.6%) of the 17 patients with Huntington disease who showed psychiatric disturbances prior to the occurrence of motor symptoms exhibited pathological raphe echogenicity (sensitivity 70.6%, specificity 68.2%). LIMITATIONS: Most of the patients were taking antichoreatic medication, which particularly influences neurologic status. Thus, a meaningful interpretation of the correlation between TCS findings and neurologic features was limited.
conclusionAs a novel finding, a relation between mesencephalic raphe echogenicity and depressive state could be identified in patients with Huntington disease. An alteration of the serotonergic brain stem raphe might be involved in the pathogenesis of depression in these patients.
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