ArticleReproductive biology and endocrinology : RB&E2010
Expression of insulin-like 3 (INSL3) and differential splicing of its receptor in the ovary of rhesus macaques.
Article in Reproductive biology and endocrinology : RB&E, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Potential ability of circulating INSL3 level for the prediction of ovarian reserve and IVF success as a novel theca cell-specific biomarker in women with unexplained infertility and diminished ovarian reserve.Reproductive biology and endocrinology : RB&E · 2025Article
- Insulin-like peptide 3 is not a biomarker for pancreatic ductal adenocarcinoma.Frontiers in endocrinology · 2025Article
- Article
- INSL3 Variation in Dogs Following Suppression and Recovery of the HPG Axis.Animals : an open access journal from MDPI · 2024Article
- ERK1/2-SOX9/FOXL2 axis regulates ovarian steroidogenesis and favors the follicular-luteal transition.Life science alliance · 2023Article
- Identification of new variants and candidate genes in women with familial premature ovarian insufficiency using whole-exome sequencing.Journal of assisted reproduction and genetics · 2022Article
- Interpretation of reproductive hormones before, during and after the pubertal transition-Identifying health and disordered puberty.Clinical endocrinology · 2021Review
- Mass Spectrometry Supports That the Structure of Circulating Human Insulin-Like Factor 3 Is a Heterodimer.Frontiers in endocrinology · 2020Article
- Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- In vitro effects of relaxin on gene expression in porcine cumulus-oocyte complexes and developing embryos.Reproductive biology and endocrinology : RB&E · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlthough insulin-like 3 (INSL3) has been identified in the gonad of both sexes in many species, there are only limited reports on the distribution of INSL3 and its receptor, relaxin/insulin-like family peptide receptor 2 (RXFP2), in the primate ovary. Since the hormone-receptor pair is believed to play a role in female reproduction, investigating the transcription of INSL3/RXFP2 genes and the spatiotemporal expression of INSL3 in the nonhuman primate may shed light on the functional aspects of the system in humans.
methodsDatabase mining, molecular and immunological methods were applied.
resultsOne single INSL3 transcript and three novel splice variant transcripts of RXFP2 were identified in the ovary of rhesus macaques. While the full-length RXFP2 transcript is barely detectable in granulosa cells during the periovulatory period, INSL3 transcript and protein are highly abundant in theca cells surrounding antral follicles. Moreover, the INSL3 level in follicular fluid is 3-4 times higher than that in female serum which remains low throughout the menstrual cycle.
conclusionsThe presence of INSL3 and its receptor in the ovary implies a potential role of the ligand-receptor pair in female reproduction in nonhuman primates. However, the existence of multiple splice variants of RXFP2 indicates a very complex nature of the hormone-receptor system.
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