Trial reportBMC cancer2010
Design of the Physical exercise during Adjuvant Chemotherapy Effectiveness Study (PACES): a randomized controlled trial to evaluate effectiveness and cost-effectiveness of physical exercise in improving physical fitness and reducing fatigue.
Trial report in BMC cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01990430 (Integrative Exercise and Life Style Intervention Increase Leisure Time Activity in Breast Cancer Patients.), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Integrative Exercise and Life Style Intervention Increase Leisure Time Activity in Breast Cancer Patients.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Physical activity interventions for disease-related physical and mental health during and following treatment in people with non-advanced colorectal cancer.The Cochrane database of systematic reviews · 2020Pooled it
- Exercise for women receiving adjuvant therapy for breast cancer.The Cochrane database of systematic reviews · 2016Pooled it
- Exercise interventions on health-related quality of life for people with cancer during active treatment.The Cochrane database of systematic reviews · 2012Pooled it
- Eight-year follow-up of patient-reported outcomes in patients with breast cancer participating in exercise studies during chemotherapy.Journal of cancer survivorship : research and practice · 2026Trial
- Muscle contractile properties of cancer patients receiving chemotherapy: Assessment of feasibility and exercise effects.Scandinavian journal of medicine & science in sports · 2020Trial
- Trial
- Cost-utility and cost-effectiveness of physical exercise during adjuvant chemotherapy.The European journal of health economics : HEPAC : health economics in prevention and care · 2018Trial
- Recruitment to and pilot results of the PACES randomized trial of physical exercise during adjuvant chemotherapy for colon cancer.International journal of colorectal disease · 2018Trial
- Supervised physical exercise to improve the quality of life of cancer patients: the EFICANCER randomised controlled trial.BMC cancer · 2015Trial
- Preliminary Outcomes of a Digital Remote Care Solution for Colorectal Cancer Patients.Cancers · 2025Article
- Article
- MicroRNAs as Potential Biomarkers for Exercise-Based Cancer Rehabilitation in Cancer Survivors.Life (Basel, Switzerland) · 2021Review
- Article
- Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes.British medical bulletin · 2021Review
- Home-Based Aerobic and Resistance Exercise Interventions in Cancer Patients and Survivors: A Systematic Review.Cancers · 2021Review
- Adherence to and satisfaction with low-intensity physical activity and supervised moderate-high intensity exercise during chemotherapy for breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Development of a computer-tailored physical activity intervention for prostate and colorectal cancer patients and survivors: OncoActive.BMC cancer · 2017Article
- Observational
- Study protocol: an evaluation of the effectiveness, experiences and costs of a patient-directed strategy compared with a multi-faceted strategy to implement physical cancer rehabilitation programmes for cancer survivors in a European healthcare system; a controlled before and after study.Implementation science : IS · 2015Article
- Modulation of the tumor vasculature and oxygenation to improve therapy.Pharmacology & therapeutics · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer chemotherapy is frequently associated with a decline in general physical condition, exercise tolerance, and muscle strength and with an increase in fatigue. While accumulating evidence suggests that physical activity and exercise interventions during chemotherapy treatment may contribute to maintaining cardiorespiratory fitness and strength, the results of studies conducted to date have not been consistent. Additional research is needed to determine the optimal intensity of exercise training programs in general and in particular the relative effectiveness of supervised, outpatient (hospital- or physical therapy practice-based) versus home-based programs.
methodsThis multicenter, prospective, randomized trial will evaluate the effectiveness of a low to moderate intensity, home-based, self-management physical activity program, and a high intensity, structured, supervised exercise program, in maintaining or enhancing physical fitness (cardiorespiratory fitness and muscle strength), in minimizing fatigue and in enhancing the health-related quality of life (HRQoL). Patients receiving adjuvant chemotherapy for breast or colon cancer (n = 360) are being recruited from twelve hospitals in the Netherlands, and randomly allocated to one of the two treatment groups or to a 'usual care' control group. Performance-based and self-reported outcomes are assessed at baseline, at the end of chemotherapy and at six month follow-up. DISCUSSION: This large, multicenter, randomized clinical trial will provide additional empirical evidence regarding the effectiveness of physical exercise during adjuvant chemotherapy in enhancing physical fitness, minimizing fatigue, and maintaining or enhancing patients' quality of life. If demonstrated to be effective, exercise intervention programs will be a welcome addition to the standard program of care offered to patients with cancer receiving chemotherapy.
trial registrationThis study is registered at the Netherlands Trial Register (NTR 2159).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.