Evidence map›Paper›PMID 21138487›Full record

ReviewThe European journal of neuroscience2011

Autophagy, inflammation and neurodegenerative disease.

Mehrdad Alirezaei, Christopher C Kemball, J Lindsay Whitton

Registry-linked trialAbstract readReview
In one paragraph

Review in The European journal of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03897101 (Autophagy, Mitophagy, Inflammation and Plasmatic Concentration of Melatonin in Newborn With Metabolic Acidosis at Birth), which is not on this map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03897101 unknown statusnot on this mapstarted 2019, after this paper: background citation

Autophagy, Mitophagy, Inflammation and Plasmatic Concentration of Melatonin in Newborn With Metabolic Acidosis at Birth

Typeobservational_patient_registrySponsorUniversity Hospital of FerraraRan2019 to 2020Enrolled150ConditionsNeonatal Encephalopathy, Cell Damage, Metabolic Acidosis, Inflammation
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 93 citations in OpenAlex.

  1. Article
  2. Article
  3. Biological Modulation of Autophagy by Nanoplastics: A Current Overview.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. The role of TRPV4 in programmed cell deaths.Molecular biology reports · 2024
    Review
  7. Journal of ginseng research · 2023
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Cell Clearing Systems Bridging Neuro-Immunity and Synaptic Plasticity.International journal of molecular sciences · 2019
    Review
  16. Article
  17. How does the brain remove its waste metabolites from within?International journal of physiology, pathophysiology and pharmacology · 2019
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mehrdad AlirezaeiDepartment of Immunology and Microbial Science, SP30-2110, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA.
Christopher C Kemball
J Lindsay Whitton
Scripps Research Institute · US

Funding

COXSACKIE MYOCARDITIS AND VIRAL PERSISTENCE IN THE HEARTR01AI042314 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WHITTON, J. LINDSAY · 1998 to 2013
$5.6M
Functional Analyses of Antiviral CD4+ T Cell ResponsesR01AI052351 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WHITTON, J. LINDSAY · 2003 to 2013
$3.9M
CYTOTOXIC T-CELL RESPONSES TO VIRUS INFECTIONR01AI027028 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WHITTON, J. LINDSAY · 1989 to 2008
$3.5M
Cytotoxic T Cell Responses to Virus InfectionR56AI027028 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WHITTON, J. LINDSAY · 2012 to 2012
$474k
Functional analyses of antiviral CD4+ T cell responsesR21AI052351 · NIAID · SCRIPPS RESEARCH INSTITUTE · PI WHITTON, J. LINDSAY · 2002 to 2002
$370k
ANALYSES OF CYTOTOXIC T CELL RESPONSE TO VIRUS INFECTIONR21AI027028 · NIAID · SCRIPPS RESEARCH INSTITUTE · PI WHITTON, J. LINDSAY · 1999 to 1999
–
NIAID NIH HHS AI-027028NIAID NIH HHS AI-042314NIAID NIH HHS AI-052351NIAID NIH HHS R01 AI027028NIAID NIH HHS R01 AI042314NIAID NIH HHS R01 AI052351NIAID NIH HHS R21 AI027028NIAID NIH HHS R21 AI052351NIAID NIH HHS R56 AI027028
6 · The paper itself

Abstract

Autophagy is emerging as a central regulator of cellular health and disease and, in the central nervous system (CNS), this homeostatic process appears to influence synaptic growth and plasticity. Herein, we review the evidence that dysregulation of autophagy may contribute to several neurodegenerative diseases of the CNS. Up-regulation of autophagy may prevent, delay or ameliorate at least some of these disorders, and - based on recent findings from our laboratory - we speculate that this goal may be achieved using a safe, simple and inexpensive approach.

Indexed as

Autoimmune DiseasesAutophagyCaloric RestrictionCentral Nervous System InfectionsHumansInflammationNeurodegenerative DiseasesNeurons

Identifiers

PMID21138487
PMCPMC3059259
OpenAlexW1514528045

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.