ArticleJournal of anatomy2011
Developmental plasticity in covariance structure of the skull: effects of prenatal stress.
Article in Journal of anatomy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Revisiting the Palimpsest: Exploring the Interaction of the Variance and Structure of Developmental Determinants of Phenotypic Covariance.Integrative and comparative biology · 2026Article
- Early life functional transitions impact craniofacial morphology in osteogenesis imperfecta.Anatomical record (Hoboken, N.J. : 2007) · 2025Article
- Unveiling Nature's Architecture: Geometric Morphometrics as an Analytical Tool in Plant Biology.Plants (Basel, Switzerland) · 2025Review
- Population-level shape variation and otolith asymmetry in Diplodus annularis.Scientific reports · 2025Article
- Adaptive or non-adaptive? Cranial evolution in a radiation of miniaturized day geckos.BMC ecology and evolution · 2024Article
- Canalization and developmental stability of the yellow-necked mouse (Apodemus flavicollis) mandible and cranium related to age and nematode parasitism.Frontiers in zoology · 2021Article
- A model of developmental canalization, applied to human cranial form.PLoS computational biology · 2021Article
- Integration and the Developmental Genetics of Allometry.Integrative and comparative biology · 2019Review
- Using network analysis to study behavioural phenotypes: an example using domestic dogs.Royal Society open science · 2016Article
- Natural history collections as windows on evolutionary processes.Molecular ecology · 2016Review
- Chronic Protein Restriction in Mice Impacts Placental Function and Maternal Body Weight before Fetal Growth.PloS one · 2016Article
- Divergence of craniofacial developmental trajectories among avian embryos.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Rate of Chiari I malformation in children of mothers with depression with and without prenatal SSRI exposure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Studying morphological integration and modularity at multiple levels: concepts and analysis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Mild reproductive effects of the Tityus bahiensis scorpion venom in rats.The journal of venomous animals and toxins including tropical diseases · 2014Article
- Phenotypic plasticity and integration in the mangrove rivulus (Kryptolebias marmoratus): a prospectus.Integrative and comparative biology · 2012Review
- Sexual dimorphism in multiple aspects of 3D facial symmetry and asymmetry defined by spatially dense geometric morphometrics.Journal of anatomy · 2012Article
- Effects of environmental perturbations during postnatal development on the phenotypic integration of the skull.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental perturbations of many kinds influence growth and development. Little is known, however, about the influence of environmental factors on the patterns of phenotypic integration observed in complex morphological traits. We analyze the changes in phenotypic variance-covariance structure of the rat skull throughout the early postnatal ontogeny (from birth to weaning) and evaluate the effect of intrauterine growth retardation (IUGR) on this structure. Using 2D coordinates taken from lateral radiographs obtained every 4 days, from birth to 21 days old, we show that the pattern of covariance is temporally dynamic from birth to 21 days. The environmental perturbation provoked during pregnancy altered the skull growth, and reduced the mean size of the IUGR group. These environmental effects persisted throughout lactancy, when the mothers of both groups received a standard diet. More strikingly, the effect grew larger beyond this point. Altering environmental conditions did not affect all traits equally, as revealed by the low correlations between covariance matrices of treatments at the same age. Finally, we found that the IUGR treatment increased morphological integration as measured by the scaled variance of eigenvalues. This increase coincided and is likely related to an increase in morphological variance in this group. This result is expected if somatic growth is a major determinant of covariance structure of the skull. In summary, our findings suggest that environmental perturbations experienced in early ontogeny alter fundamental developmental processes and are an important factor in shaping the variance-covariance structure of complex phenotypic traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.